K
Ken Takahashi
Researcher at Osaka University
Publications - 7
Citations - 3521
Ken Takahashi is an academic researcher from Osaka University. The author has contributed to research in topics: Innate immune system & Proinflammatory cytokine. The author has an hindex of 5, co-authored 5 publications receiving 3336 citations. Previous affiliations of Ken Takahashi include Kyoto University.
Papers
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Journal ArticleDOI
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
Taro Kawai,Ken Takahashi,Ken Takahashi,Shintaro Sato,Cevayir Coban,Himanshu Kumar,Hiroki Kato,Ken Ishii,Osamu Takeuchi,Shizuo Akira +9 more
TL;DR: IPS-1 contained an N-terminal CARD-like structure that mediated interaction with the CARD of RIG-I and Mda5, which are cytoplasmic RNA helicases that sense viral infection and blocked interferon induction by virus infection.
Journal ArticleDOI
A Toll-like receptor–independent antiviral response induced by double-stranded B-form DNA
Ken Ishii,Cevayir Coban,Hiroki Kato,Ken Takahashi,Yuichi Torii,Fumihiko Takeshita,Holger Ludwig,Gerd Sutter,Koichi Suzuki,Hiroaki Hemmi,Shintaro Sato,Masahiro Yamamoto,Satoshi Uematsu,Taro Kawai,Osamu Takeuchi,Shizuo Akira +15 more
TL;DR: It is shown that intracellular administration of double-stranded B-form DNA triggered antiviral responses including production of type I interferons and chemokines independently of Toll-like receptors or the helicase RIG-I.
Journal ArticleDOI
Roles of caspase-8 and caspase-10 in innate immune responses to double-stranded RNA.
TL;DR: Results indicate that caspase-8 and caspases are essential components that mediate NF-κB-dependent inflammatory responses in antiviral signaling.
Journal ArticleDOI
NLRC5 Deficiency Does Not Influence Cytokine Induction by Virus and Bacteria Infections
Himanshu Kumar,Surya Pandey,Jian Zou,Yutaro Kumagai,Ken Takahashi,Ken Takahashi,Shizuo Akira,Taro Kawai +7 more
TL;DR: It is indicated that NLRC5 is dispensable for cytokine induction in virus and bacterial infections under physiologic conditions and controls IL-1β production through an unidentified pathway.