K
Ken Ishii
Researcher at International University of Health and Welfare
Publications - 593
Citations - 37498
Ken Ishii is an academic researcher from International University of Health and Welfare. The author has contributed to research in topics: Immune system & Innate immune system. The author has an hindex of 83, co-authored 537 publications receiving 33230 citations. Previous affiliations of Ken Ishii include Daiichi Sankyo & University of Tokyo.
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Journal ArticleDOI
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
Hiroki Kato,Osamu Takeuchi,Shintaro Sato,Mitsutoshi Yoneyama,Masahiro Yamamoto,Kosuke Matsui,Satoshi Uematsu,Andreas Jung,Taro Kawai,Ken Ishii,Osamu Yamaguchi,Kinya Otsu,Tohru Tsujimura,Chang-Sung Koh,Caetano Reis e Sousa,Yoshiharu Matsuura,Takashi Fujita,Shizuo Akira +17 more
TL;DR: It is found that RIG-I is essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus and Japanese encephalitis virus, whereas MDA5 is critical for picornavirus detection.
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IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
Taro Kawai,Ken Takahashi,Ken Takahashi,Shintaro Sato,Cevayir Coban,Himanshu Kumar,Hiroki Kato,Ken Ishii,Osamu Takeuchi,Shizuo Akira +9 more
TL;DR: IPS-1 contained an N-terminal CARD-like structure that mediated interaction with the CARD of RIG-I and Mda5, which are cytoplasmic RNA helicases that sense viral infection and blocked interferon induction by virus infection.
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Interferon-|[alpha]| induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6
Taro Kawai,Shintaro Sato,Ken Ishii,Cevayir Coban,Hiroaki Hemmi,Masahiro Yamamoto,Kenta Terai,Michiyuki Matsuda,Jun-ichiro Inoue,Satoshi Uematsu,Osamu Takeuchi,Shizuo Akira +11 more
TL;DR: It is shown that TLR-mediated IFN-α induction requires the formation of a complex consisting of MyD88, TRAF6 and IRF7 as well as TRAF 6-dependent ubiquitination.
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Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury.
Seiji Okada,Masaya Nakamura,Hiroyuki Katoh,Tamaki Miyao,Takuya Shimazaki,Ken Ishii,Junichi Yamane,Akihiko Yoshimura,Yukihide Iwamoto,Yoshiaki Toyama,Hideyuki Okano +10 more
TL;DR: It is suggested that Stat3 is a key regulator of reactive astrocytes in the healing process after SCI, providing a potential target for intervention in the treatment of CNS injury.
Journal ArticleDOI
A Toll-like receptor–independent antiviral response induced by double-stranded B-form DNA
Ken Ishii,Cevayir Coban,Hiroki Kato,Ken Takahashi,Yuichi Torii,Fumihiko Takeshita,Holger Ludwig,Gerd Sutter,Koichi Suzuki,Hiroaki Hemmi,Shintaro Sato,Masahiro Yamamoto,Satoshi Uematsu,Taro Kawai,Osamu Takeuchi,Shizuo Akira +15 more
TL;DR: It is shown that intracellular administration of double-stranded B-form DNA triggered antiviral responses including production of type I interferons and chemokines independently of Toll-like receptors or the helicase RIG-I.