Kendall Mitchell

TL;DR: Behavioral recovery following peripheral RTX treatment is linked to regeneration of TRPV1-expressing Adelta and C-fibers and sustained expression of molecular markers and Infrared laser stimulation is a potentially valuable tool for evaluating the behavioral role of Adelta fibers in pain and pain control.

TL;DR: Topical RTX analgesia did not impair epithelial wound healing, left the blink reflex intact and occurred without detectable histological damage to the cornea, suggesting that RTX may be a safe and effective treatment for post‐operative or post‐injury ophthalmic pain.

TL;DR: It is shown that stimulating either subtype of TRPV1+ fiber in the paw during carrageenan‐induced inflammation or following hind‐paw incision elicits pronounced hyperalgesic responses, including prolonged paw guarding, which suggest multiple roles for TRPv1+ A&dgr; fibers in nociceptive processes and their modulation of pathological pain conditions.

TL;DR: The results are consistent with the idea that monocyte chemoattractant protein‐1 at the site of peripheral injury and/or in DRG is involved in inflammatory hyperalgesia.

TL;DR: The data raise the possibility that selective populations of leukocytes may communicate the presence of disease or tissue damage from the periphery to cells in the central nervous system through the endothelial blood–brain barrier.