K
Kenjiro Sakaki
Researcher at University of Michigan
Publications - 7
Citations - 1369
Kenjiro Sakaki is an academic researcher from University of Michigan. The author has contributed to research in topics: Unfolded protein response & Endoplasmic reticulum. The author has an hindex of 6, co-authored 7 publications receiving 1290 citations.
Papers
More filters
Journal ArticleDOI
Endoplasmic Reticulum Stress Activates Cleavage of CREBH to Induce a Systemic Inflammatory Response
Kezhong Zhang,Xiaohua Shen,Jun Wu,Kenjiro Sakaki,Thomas L. Saunders,D. Thomas Rutkowski,Sung Hoon Back,Randal J. Kaufman +7 more
TL;DR: The studies delineate a molecular mechanism for activation of an ER-localized transcription factor, CREBH, and reveal an unprecedented link by which ER stress initiates an acute inflammatory response.
Journal ArticleDOI
Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans.
TL;DR: Microarray analysis identified inducible UPR (i-UPR) genes, as well as numerous constitutive UPR genes that require the ER stress transducers during normal development and identified the liver-specific transcription factor CREBh as a novel UPR gene conserved during metazoan evolution.
Journal ArticleDOI
Protein Kinase Cθ Is Required for Autophagy in Response to Stress in the Endoplasmic Reticulum
TL;DR: It is reported that ER stress-induced autophagy requires the activation of protein kinase Cθ (PKCθ), a member of the noveltype PKC family, and Ca2+-dependent PKCθ activation is specifically required for autophagic response to ER stress but not in response to amino acid starvation.
Journal ArticleDOI
RNA surveillance is required for endoplasmic reticulum homeostasis
Kenjiro Sakaki,Sawako Yoshina,Xiaohua Shen,Jaeseok Han,Melinda R. DeSantis,Mon Xiong,Shohei Mitani,Randal J. Kaufman +7 more
TL;DR: These results demonstrate a unique and fundamental interaction where NMD-mediated mRNA quality control is required to prevent ER stress and sensitize to the lethal effects of ER stress.
Journal ArticleDOI
Regulation of ER stress-induced macroautophagy by protein kinase C.
Kenjiro Sakaki,Randal J. Kaufman +1 more
TL;DR: The findings have shown that ER stress, in a Ca2+-dependent manner, induces PKCθ phosphorylation within the activation loop and localization with LC3-II in punctate cytoplasmic structures, and the significance of these findings is discussed.