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Kenneth Burnside Ramsay Ewan
Researcher at Cardiff University
Publications - 21
Citations - 1135
Kenneth Burnside Ramsay Ewan is an academic researcher from Cardiff University. The author has contributed to research in topics: Wnt signaling pathway & Signal transduction. The author has an hindex of 13, co-authored 21 publications receiving 1001 citations. Previous affiliations of Kenneth Burnside Ramsay Ewan include Lawrence Berkeley National Laboratory.
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Journal Article
Transforming growth factor-beta1 mediates cellular response to DNA damage in situ.
Kenneth Burnside Ramsay Ewan,Rhonda L. Henshall-Powell,Shraddha A. Ravani,Maria Jose Pajares,Carlos L. Arteaga,Ray Warters,Rosemary J. Akhurst,Mary Helen Barcellos-Hoff +7 more
TL;DR: Data indicate that TGF-beta1 is essential for rapid p53-mediated cellular responses that mediate cell fate decisions in situ, and that both apoptosis and inhibition of proliferation in response to DNA damage decrease as a function of Tgfbeta1 gene dose in embryonic epithelial tissues.
Journal ArticleDOI
Latent Transforming Growth Factor-β Activation in Mammary Gland: Regulation by Ovarian Hormones Affects Ductal and Alveolar Proliferation
Kenneth Burnside Ramsay Ewan,G. Shyamala,Shradda A. Ravani,Yang Tang,Rosemary J. Akhurst,Lalage M. Wakefield,Mary Helen Barcellos-Hoff +6 more
TL;DR: It is suggested that ovarian hormones regulate TGF-beta 1 activation, which in turn restricts proliferative response to hormone signaling, and thus activity are regulated by ovarian hormones.
Journal ArticleDOI
A Useful Approach to Identify Novel Small-Molecule Inhibitors of Wnt-Dependent Transcription
Kenneth Burnside Ramsay Ewan,Bożena Pajak,Mark Stubbs,Helen Todd,Olivier Barbeau,Camilo E. Quevedo,Hannah Botfield,Rodrigo M. Young,Ruth Ruddle,Lee Samuel,Alysia Battersby,Florence I. Raynaud,Nicholas D. Allen,Stephen W. Wilson,Branko V. Latinkić,Paul Workman,Edward McDonald,Julian Blagg,Wynne Aherne,Trevor Clive Dale +19 more
TL;DR: A practical approach to identify small-molecule inhibitors of Wnt signaling that can seed the development of agents suitable to treat patients with Wnt-dependent tumors is illustrated.
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A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease
Trevor Clive Dale,Paul A. Clarke,Christina Esdar,Dennis Waalboer,Olajumoke Adeniji-Popoola,Maria-Jesus Ortiz-Ruiz,Aurélie Mallinger,Rahul S. Samant,Paul Czodrowski,Djordje Musil,Daniel Schwarz,Klaus Schneider,Mark Stubbs,Kenneth Burnside Ramsay Ewan,Elizabeth Fraser,Robert TePoele,Will Court,Gary Box,Melanie Valenti,Alexis De Haven Brandon,Sharon Gowan,Felix Rohdich,Florence I. Raynaud,Richard Schneider,Oliver Poeschke,Andree Blaukat,Paul Workman,Kai Schiemann,Suzanne A. Eccles,Dirk Wienke,Julian Blagg +30 more
TL;DR: It is determined that CCT251545, a small molecule WNT-pathway inhibitor discovered through cell-based screening, is a potent and selective chemical probe for the human Mediator complex-associated protein kinases CDK8 and CDK19 with >100-fold selectivity over 291 other kinases.
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Proliferation of Estrogen Receptor-α-Positive Mammary Epithelial Cells Is Restrained by Transforming Growth Factor-β1 in Adult Mice
Kenneth Burnside Ramsay Ewan,Hellen A. Oketch-Rabah,Shradda A. Ravani,G. Shyamala,Harold L. Moses,Mary Helen Barcellos-Hoff +5 more
TL;DR: TGF-β1 activation functionally restrains ER-α-positive cells from proliferating in adult mammary gland, and it is proposed that TGF- β1 dysregulation may promote proliferation of ER- α- positive cells associated with breast cancer risk in humans.