N
Nicholas D. Allen
Researcher at Cardiff University
Publications - 112
Citations - 6278
Nicholas D. Allen is an academic researcher from Cardiff University. The author has contributed to research in topics: Induced pluripotent stem cell & Embryonic stem cell. The author has an hindex of 41, co-authored 106 publications receiving 5673 citations. Previous affiliations of Nicholas D. Allen include UCL Institute of Ophthalmology & Merck & Co..
Papers
More filters
Journal ArticleDOI
Induced Pluripotent Stem Cells from Patients with Huntington’s Disease : Show CAG Repeat-Expansion-Associated Phenotypes
Virginia B. Mattis,Soshana P. Svendsen,Allison D. Ebert,Clive N. Svendsen,Alvin R. King,Malcolm Casale,Sara T. Winokur,Gayani Batugedara,Marquis P. Vawter,Peter J. Donovan,Leslie F. Lock,Leslie M. Thompson,Yu Zhu,Elisa Fossale,Ranjit Singh Atwal,Tammy Gillis,Jayalakshmi S. Mysore,Jian Hong Li,Ihn Sik Seong,Yiping Shen,Xiaoli Chen,Vanessa C. Wheeler,Marcy E. MacDonald,James F. Gusella,Sergey S Akimov,Nicolas Arbez,Tarja A. Juopperi,Tamara Ratovitski,Jason H. Chiang,Woon Roung Kim,Eka Chighladze,Erin Watkin,Chun Zhong,Georgia Makri,Robert N. Cole,Russell L. Margolis,Hongjun Song,Guo Li Ming,Christopher A. Ross,Julia A. Kaye,Julia A. Kaye,Aaron C. Daub,Aaron C. Daub,Punita Sharma,Punita Sharma,Amanda R. Mason,Amanda R. Mason,Steven Finkbeiner,Steven Finkbeiner,Junying Yu,James A. Thomson,David Rushton,Stephen P. Brazier,Alysia Battersby,Amanda Redfern,Hsui Er Tseng,Alexander William John Harrison,Paul J. Kemp,Nicholas D. Allen,Marco Onorati,Valentina Castiglioni,Elena Cattaneo,Jamshid Arjomand +62 more
TL;DR: The generation and characterization of 14 induced pluripotent stem cell (iPSC) lines from HD patients and controls reveal CAG-repeat-expansion-associated gene expression patterns that distinguish patient lines from controls, and early onset versus late onset HD.
Journal ArticleDOI
A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response
Walther Haenseler,Stephen N. Sansom,Julian Buchrieser,Sarah E. Newey,Craig S. Moore,Francesca J. Nicholls,Satyan Chintawar,Christian Schnell,Jack P. Antel,Nicholas D. Allen,M Z Cader,Richard Wade-Martins,William James,Sally A. Cowley +13 more
TL;DR: Co-culture microglia downregulate pathogen-response pathways, upregulate homeostatic function pathways, and promote a more anti-inflammatory and pro-remodeling cytokine response than corresponding monocultures, demonstrating that co-cultures are preferable for modeling authentic microglial physiology.
Journal ArticleDOI
Transactivation of Igf2 in a mouse model of Beckwith–Wiedemann syndrome
TL;DR: Igf2 overexpression is established as a key determinant of Beckwith–Wiedemann syndrome after being introduced into the mouse genome by using embryonic stem cells, which leads to transactivation of the endogenous Igf2 gene.
Journal ArticleDOI
Developmental control of allelic methylation in the imprinted mouse Igf2 and H19 genes
TL;DR: The results suggest that allelic methylation patterns in Igf2 and H19 arise early in embryogenesis and change progressively during development, some of these developmental changes are apparently under tissue-specific control.
Journal ArticleDOI
Mice lacking the giant protocadherin mFAT1 exhibit renal slit junction abnormalities and a partially penetrant cyclopia and anophthalmia phenotype.
TL;DR: A necessary role for FAT1 in the modified adhesion junctions of the renal glomerular epithelial cell is confirmed and hitherto unsuspected roles for FAT 1 in CNS development are revealed.