K
Kenneth M. Tichauer
Researcher at Illinois Institute of Technology
Publications - 168
Citations - 1964
Kenneth M. Tichauer is an academic researcher from Illinois Institute of Technology. The author has contributed to research in topics: Molecular imaging & Imaging agent. The author has an hindex of 25, co-authored 149 publications receiving 1721 citations. Previous affiliations of Kenneth M. Tichauer include Robarts Research Institute & Dartmouth College.
Papers
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Journal ArticleDOI
In Vivo Quantification of Tumor Receptor Binding Potential with Dual-Reporter Molecular Imaging
Kenneth M. Tichauer,Kimberley S. Samkoe,Kristian J. Sexton,Shannon K. Hextrum,Harold H. Yang,W. Spencer Klubben,Jason R. Gunn,Tayyaba Hasan,Brian W. Pogue,Brian W. Pogue +9 more
TL;DR: By providing a fast and robust measure of receptor density in tumors, the presented methodology has powerful implications for improving choices in cancer intervention, evaluation, and monitoring, and can be scaled to the clinic with an imaging modality like SPECT.
Journal ArticleDOI
Microscopic lymph node tumor burden quantified by macroscopic dual-tracer molecular imaging.
Kenneth M. Tichauer,Kimberley S. Samkoe,Jason R. Gunn,Stephen C. Kanick,P. Jack Hoopes,Richard J. Barth,Peter A. Kaufman,Tayyaba Hasan,Brian W. Pogue +8 more
TL;DR: A method of correcting for nonspecific uptake with injection of a second untargeted tracer that allows for quantification of tumor burden in lymph nodes is presented and confirmed in an athymic mouse model of metastatic human breast cancer by targeting epidermal growth factor receptor.
Journal ArticleDOI
Dynamic dual-tracer MRI-guided fluorescence tomography to quantify receptor density in vivo
Scott C. Davis,Kimberley S. Samkoe,Kenneth M. Tichauer,Kenneth M. Tichauer,Kristian J. Sexton,Jason R. Gunn,Sophie J. Deharvengt,Tayyaba Hasan,Brian W. Pogue,Brian W. Pogue +9 more
TL;DR: A dual-tracer optical technique is presented for noninvasive estimation of specific receptor binding in cancer using a multispectral MRI-coupled fluorescence molecular tomography system to image the uptake kinetics of two fluorescent tracers injected simultaneously.
Journal ArticleDOI
Quantitative in vivo cell-surface receptor imaging in oncology: kinetic modeling and paired-agent principles from nuclear medicine and optical imaging.
TL;DR: Approaches for overcoming limitations based upon tracer kinetic modeling and the use of emerging protocols to estimate binding potential and the related receptor concentration are reviewed.
Journal ArticleDOI
Comparison of time-resolved and continuous-wave near-infrared techniques for measuring cerebral blood flow in piglets
Mamadou Diop,Kenneth M. Tichauer,Jonathan T. Elliott,Mark Migueis,Ting-Yim Lee,Keith St. Lawrence +5 more
TL;DR: Results demonstrate that TR-NIR can measure CBF with reasonable accuracy and is sensitive to flow changes, and could be caused by differences in depth sensitivities between continuous-wave and time-resolved measurements.