Kent D. Butz

TL;DR: The MRI-based approach may accelerate the development of regenerative therapies for diseased or damaged cartilage, which is currently limited by the lack of reliable in vivo methods for noninvasive assessment of functional changes following treatment.

TL;DR: Results show that microCT-based finite element analysis combined with strain gauge measures provides detailed resolution of the tissue-level strain in both the cancellous and cortical bones of the mouse tibia during in vivo compression loading, which is necessary for interpreting localized patterns of modeling/remodeling and, potentially, gene and protein expression in skeletal mechanobiology studies.

TL;DR: The results demonstrate the feasibility of a new and computationally efficient technique incorporating MRI-based deformation with mathematical modeling to non-invasively evaluate the mechanical behavior of biological tissues and materials.

TL;DR: Analysis of finger joints occurring during activities such as typing at a keyboard, playing piano, gripping a pen, carrying a weight and opening a jar indicates that joint forces in excess of 100 N may be common at the metacarpophalangeal joint.

TL;DR: The application of prestress minimized skin deflection during needle penetration and allowed for needle actuation to the targeted penetration depths with minimum variability, and the force required to achieve target penetration depths was found to increase with prestress and decrease with needle gauge.