K
Kenta Tsunekuni
Researcher at Osaka University
Publications - 12
Citations - 373
Kenta Tsunekuni is an academic researcher from Osaka University. The author has contributed to research in topics: Cancer & Tipiracil. The author has an hindex of 8, co-authored 12 publications receiving 282 citations.
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Journal ArticleDOI
Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial–mesenchymal transition
Atsushi Hamabe,Masamitsu Konno,Nobuhiro Tanuma,Hiroshi Shima,Kenta Tsunekuni,Koichi Kawamoto,Naohiro Nishida,Jun Koseki,Koshi Mimori,Noriko Gotoh,Hirofumi Yamamoto,Yuichiro Doki,Masaki Mori,Hideshi Ishii +13 more
TL;DR: It is reported that stimulation of epithelial–mesenchymal transition (EMT) results in the nuclear translocation of PKM2 in colon cancer cells, which is pivotal in promoting EMT.
Journal ArticleDOI
Oncometabolite D-2-Hydroxyglurate Directly Induces Epithelial-Mesenchymal Transition and is Associated with Distant Metastasis in Colorectal Cancer
Hugh Colvin,Naohiro Nishida,Masamitsu Konno,Naotsugu Haraguchi,Hidekazu Takahashi,Junichi Nishimura,Taishi Hata,Koichi Kawamoto,Ayumu Asai,Kenta Tsunekuni,Jun Koseki,Tsunekazu Mizushima,Taroh Satoh,Yuichiro Doki,Masaki Mori,Hideshi Ishii +15 more
TL;DR: D-2HG levels were elevated in colorectal cancer specimens, particularly in those associated with distant metastasis, supporting the observations in vitro and implicating the contribution of D- 2HG in metastases, the major cause of death in this disease.
Journal ArticleDOI
The importance of mitochondrial folate enzymes in human colorectal cancer
Masaaki Miyo,Masamitsu Konno,Hugh Colvin,Naohiro Nishida,Jun Koseki,Koichi Kawamoto,Kenta Tsunekuni,Junichi Nishimura,Taishi Hata,Ichiro Takemasa,Tsunekazu Mizushima,Yuichiro Doki,Masaki Mori,Hideshi Ishii +13 more
TL;DR: expression of three mitochondrial folate metabolic enzymes, serine hydroxymethyl transferase (SHMT2), methylenetetrahydrofolate dehydrogenase (MTHFD2) and aldehyde dehydrogenases 1 family member L2 (ALDH1L2), were upregulated in human colorectal tumor tissues compared to normal tissues, suggesting that mitochondrial folATE metabolic enzymes could provide a potential therapeutic strategy for treating colore CT cancer.
Journal ArticleDOI
CD44/CD133-Positive Colorectal Cancer Stem Cells are Sensitive to Trifluridine Exposure
Kenta Tsunekuni,Masamitsu Konno,Naotsugu Haraguchi,Jun Koseki,Ayumu Asai,Kazuaki Matsuoka,Takashi Kobunai,Teiji Takechi,Yuichiro Doki,Masaki Mori,Masaki Mori,Hideshi Ishii +11 more
TL;DR: The data show that trifluridine (FTD) treatment is effective against CSC-like cells and might be applied as C SCs-targeting chemotherapy for tumor subtypes with high CD44 and CD133 expression.
Journal ArticleDOI
Mathematical analysis predicts imbalanced IDH1/2 expression associates with 2-HG-inactivating β-oxygenation pathway in colorectal cancer
Jun Koseki,Hugh Colvin,Takahito Fukusumi,Naohiro Nishida,Masamitsu Konno,Koichi Kawamoto,Kenta Tsunekuni,Hidetoshi Matsui,Yuichiro Doki,Masaki Mori,Hideshi Ishii +10 more
TL;DR: A novel methodology to computationally analyze gene expression in colorectal cancer (CRC) is developed, and novel sets of genes that are associated with patient survival are identified, providing a strong rationale for studying this mechanism further in order to discover novel therapeutic targets for the treatment of CRC.