N
Noriko Gotoh
Researcher at Kanazawa University
Publications - 112
Citations - 7887
Noriko Gotoh is an academic researcher from Kanazawa University. The author has contributed to research in topics: Cancer & Phosphorylation. The author has an hindex of 39, co-authored 108 publications receiving 6944 citations. Previous affiliations of Noriko Gotoh include Tokyo Medical and Dental University & New York University.
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Journal ArticleDOI
Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells
Shin-ichiro Ohno,Masakatsu Takanashi,Katsuko Sudo,Shinobu Ueda,Akio Ishikawa,Nagahisa Matsuyama,Koji Fujita,Takayuki Mizutani,Tadaaki Ohgi,Takahiro Ochiya,Noriko Gotoh,Masahiko Kuroda +11 more
TL;DR: It is shown that exosomes can efficiently deliver microRNA (miRNA) to epidermal growth factor receptor (EGFR)-expressing breast cancer cells, and the results suggest that exOSomes can be used therapeutically to target EGFR-expressing cancerous tissues with nucleic acid drugs.
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Identification of genes upregulated in ALK-positive and EGFR/KRAS/ALK-negative lung adenocarcinomas.
Hirokazu Okayama,Takashi Kohno,Yuko Ishii,Yoko Shimada,Kouya Shiraishi,Reika Iwakawa,Koh Furuta,Koji Tsuta,Tatsuhiro Shibata,Seiichiro Yamamoto,Shun-ichi Watanabe,Hiromi Sakamoto,Kensuke Kumamoto,Seiichi Takenoshita,Noriko Gotoh,Hideaki Mizuno,Akinori Sarai,Shuichi Kawano,Rui Yamaguchi,Satoru Miyano,Jun Yokota +20 more
TL;DR: An extensive genome-wide expression profiling of 226 primary human stage I-II lung adenocarcinomas helps identify patients who may gain the most benefit from adjuvant chemotherapy after surgical resection and further stratify more or less aggressive subgroups of triple-negative lung ADC.
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Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms.
Masashi Sanada,Takahiro Suzuki,Lee-Yung Shih,Makoto Otsu,Motohiro Kato,Satoshi Yamazaki,Azusa Tamura,Hiroaki Honda,Mamiko Sakata-Yanagimoto,Keiki Kumano,Hideaki Oda,Tetsuya Yamagata,Junko Takita,Noriko Gotoh,Kumi Nakazaki,Norihiko Kawamata,Masafumi Onodera,Masaharu Nobuyoshi,Yasuhide Hayashi,Hiroshi Harada,Mineo Kurokawa,Shigeru Chiba,Hiraku Mori,Keiya Ozawa,Mitsuhiro Omine,Hisamaru Hirai,Hiromitsu Nakauchi,H. Phillip Koeffler,Seishi Ogawa +28 more
TL;DR: In this paper, gain-of-function mutations of the C-CBL (also known as CBL) tumour suppressor are tightly associated with acquired uniparental disomy (aUPD) in myeloid neoplasms showing myeloproliferative features.
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FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors.
TL;DR: This experiment suggests that FGFR1 may regulate signaling via NGF receptors by sequestering a common key element which both receptors utilize for transmitting their signals.
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DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane.
Hideki Hasegawa,Etsuko Kiyokawa,Shinya Tanaka,Kazuo Nagashima,Noriko Gotoh,Masabumi Shibuya,Takeshi Kurata,Michiyuki Matsuda +7 more
TL;DR: The results suggest that DOCK180 is a new effector molecule which transduces signals from tyrosine kinases through the CRK adaptor protein.