Keren Hirsch

TL;DR: It is suggested that lycopene inhibits cell cycle progression via reduction of the cyclin D level and retention of p27 in cyclin E–cdk2, thus leading to inhibition of G1 CDK activities.

TL;DR: It is suggested that allicin plays a major role in the antiproliferative effect of water-soluble garlic preparations and that this effect may be attributed to the ability ofallicin to transiently deplete the intracellular GSH level.

TL;DR: The results suggest that dietary carotenoids inhibit estrogen signaling of both 17β-estradiol and genistein, and attenuate their deleterious effect in hormone-dependent malignancies.

TL;DR: It is found that lycopene can synergize with other phytonutrients in the inhibition of cancer cell growth and is feasible to suggest that carotenoids and their oxidized derivatives interact with a network of transcription systems that are activated by different ligands at low affinity and specificity and that this activation leads to the synergistic inhibition of cell growth.

TL;DR: This review will primarily address the mechanisms proposed for the cancer preventive activity of tomato lycopene, focusing on the induction of phase II enzymes and the inhibition of growth factors and sex hormones such as estrogens and androgens.