K
Kerry L. Dearfield
Researcher at Food Safety and Inspection Service
Publications - 66
Citations - 3302
Kerry L. Dearfield is an academic researcher from Food Safety and Inspection Service. The author has contributed to research in topics: Risk assessment & Genotoxicity. The author has an hindex of 32, co-authored 65 publications receiving 3085 citations. Previous affiliations of Kerry L. Dearfield include United States Environmental Protection Agency & United States Department of Agriculture.
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Journal ArticleDOI
Acrylamide: its metabolism, developmental and reproductive effects, genotoxicity, and carcinogenicity.
TL;DR: The data show that acrylamide is capable of inducing genotoxic, carcinogenic, developmental, and reproductive effects in tested organisms and may pose more than a neurotoxic health hazard to exposed humans.
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Acrylamide: a review of its genotoxicity and an assessment of heritable genetic risk.
Kerry L. Dearfield,George R. Douglas,U.H. Ehling,Martha M. Moore,Gary A. Sega,David J. Brusick +5 more
TL;DR: Using data from the studies generating quantitative information concerning heritability of genetic effects, an assessment of the heritable genetic risk presented by acrylamide is presented and estimates for inhalation or dermal exposures suggest higher risks for induced genetic disease in offspring from fathers exposed in occupational settings.
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ReviewSister-chromatid exchange: second report of the Gene-Tox program
James D. Tucker,Angela E. Auletta,Michael C. Cimino,Kerry L. Dearfield,David Jacobson-Kram,Raymond R. Tice,Anthony V. Carrano +6 more
TL;DR: In this article, the ability of a number of chemicals to induce sister-chromatid exchanges (SCEs) was reviewed, and the SCE data for animal cells in vivo and in vitro, and human cells in vitro were presented in 6 tables according to their relative effectiveness.
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Genotoxicity risk assessment: a proposed classification strategy.
TL;DR: The scheme that follows provides a proposed harmonization approach in which genotoxicity assessments are fully developed within the risk Assessment paradigm used by EPA, and sets out a process that integrates newer thinking in testing battery design with the risk assessment process.
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Quantitative approaches for assessing dose–response relationships in genetic toxicology studies
B. Bhaskar Gollapudi,George E. Johnson,Lya G. Hernández,Lynn H. Pottenger,Kerry L. Dearfield,Alan M. Jeffrey,E. Julien,James H. Kim,David P. Lovell,James T. MacGregor,Martha M. Moore,J. van Benthem,Paul D. White,Errol Zeiger,Véronique Thybaud +14 more
TL;DR: The results indicate that the lower confidence limit of a benchmark response rate of 10% could be considered a satisfactory POD when analyzing genotoxicity data using the BMD approach, and the models described permit the identification of POD values that could be combined with mode of action analysis to determine whether exposure below a particular level constitutes a significant human risk.