R
Raymond R. Tice
Researcher at National Institutes of Health
Publications - 126
Citations - 20695
Raymond R. Tice is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Genotoxicity & DNA damage. The author has an hindex of 51, co-authored 125 publications receiving 19138 citations. Previous affiliations of Raymond R. Tice include University of North Carolina at Chapel Hill & Research Triangle Park.
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A simple technique for quantitation of low levels of DNA damage in individual cells
TL;DR: Human lymphocytes were exposed to X-irradiation or treated with H2O2 and the extent of DNA migration was measured using a single-cell microgel electrophoresis technique under alkaline conditions and this technique appears to be sensitive and useful for detecting damage and repair in single cells.
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Recommendations for conducting the in vivo alkaline Comet assay
Andreas Hartmann,E. Agurell,Carol Beevers,Susanne Brendler-Schwaab,Brian Burlinson,P. Clay,Andrew Collins,A. Smith,Günter Speit,Véronique Thybaud,Raymond R. Tice +10 more
TL;DR: This paper is intended to act as an update to the more general guidelines which were published as a result of the International Workshop on Genotoxicity Test Procedures, and is seen as a major step towards gaining more formal regulatory acceptance of the Comet assay.
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IPCS guidelines for the monitoring of genotoxic effects of carcinogens in humans
Richard J. Albertini,Diana Anderson,George R. Douglas,Lars Hagmar,Kari Hemminki,Franco Merlo,Adayapalam T. Natarajan,Hannu Norppa,David E. G. Shuker,Raymond R. Tice,Michael D. Waters,Antero Aitio +11 more
TL;DR: The most commonly studied genotoxicity endpoints have been selected for inclusion in this document and they are structural and numerical chromosomal aberrations assessed using cytogenetic methods (classical chromosomal aberration analysis (CA), fluorescence in situ hybridisation (FISH), micronuclei (MN), DNA damage (adducts, strand breaks, crosslinking, alkali-labile sites) assessed using bio-chemical/electrophoretic assays or sister chromatid exchanges (SCE); protein adducts; and hypoxanthine-
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Sister-chromatid exchanges: a report of the GENE-TOX program.
Samuel A. Latt,James W. Allen,Stephen E. Bloom,Anthony V. Carrano,Ernest Falke,David Kram,David Kram,Edward L. Schneider,Rhona Schreck,Raymond R. Tice,Brad Whitfield,Sheldon Wolff +11 more
TL;DR: The data support the concept that SCEs provide a useful indication of exposure, although the mechanism and biological significance of SCE formation still remain to be elucidated.
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Improving the Human Hazard Characterization of Chemicals: A Tox21 Update
TL;DR: The Tox21 partners agreed to develop a vision and devise an implementation strategy to shift the assessment of chemical hazards away from traditional experimental animal toxicology studies to one based on target-specific, mechanism-based, biological observations largely obtained using in vitro assays.