Kerstin N. Schmidt

TL;DR: The data show that one ROI species, H2O2 acts as a messenger in the TNF- and okadaic acid-induced post-translational activation of NF-kappa B, and explains the inhibitory effects of many antioxidative compounds on the activation of the inducible, higher eukaryotic transcription factor.

TL;DR: In this paper, the comparative efficacy and procedural safety of open irrigated radiofrequency (RF) and cryoballoon catheter (CB) ablation for pulmonary vein isolation in patients with paroxysmal atrial fibrillation were evaluated.

TL;DR: While NF-κB may be indispensable as inducer of many immediate-early inflammatory and immune reactions, the transcription factor is likely to play a fatal role in certain diseases and syndromes that involve an abberrant expression of inflammatory cytokines.

TL;DR: The data provide long-term evidence that CB ablation is non-inferior to RF ablation, with high proportions of patients reporting freedom from AF 30 months after the index procedure.

TL;DR: Local impedance measurements demonstrated their capability to distinguish pathological atrial tissue from physiological substrate, indicating that electrogram- and impedance-based substrate mapping have the potential to complement each other toward better patient outcomes in future.