P
Paul Amstad
Researcher at University of Maryland, Baltimore
Publications - 36
Citations - 3465
Paul Amstad is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Superoxide dismutase & Cell culture. The author has an hindex of 23, co-authored 36 publications receiving 3361 citations.
Papers
More filters
Journal Article
Increased p53 mutation load in noncancerous colon tissue from ulcerative colitis: a cancer-prone chronic inflammatory disease.
S P Hussain,Paul Amstad,K Raja,Stefan Ambs,Makoto Nagashima,William P. Bennett,Peter G. Shields,A J Ham,J A Swenberg,Aizen J. Marrogi,Chris Harris +10 more
TL;DR: The data are consistent with the hypothesis that a higher frequency of p53 mutant cells can be generated under oxidative stress in people with UC and may confer susceptibility to the development of CRC in an inflammatory microenvironment.
Journal ArticleDOI
The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-κB
TL;DR: The data show that one ROI species, H2O2 acts as a messenger in the TNF- and okadaic acid-induced post-translational activation of NF-kappa B, and explains the inhibitory effects of many antioxidative compounds on the activation of the inducible, higher eukaryotic transcription factor.
Journal ArticleDOI
p53-induced up-regulation of MnSOD and GPx but not catalase increases oxidative stress and apoptosis.
S. Perwez Hussain,Paul Amstad,Peijun He,Ana I. Robles,Shawn E. Lupold,Ichiro Kaneko,Masato Ichimiya,Sagar Sengupta,Leah E. Mechanic,Shu Okamura,Lorne J. Hofseth,Matthew Moake,Makoto Nagashima,Kathleen Forrester,Curtis C. Harris +14 more
TL;DR: A novel mechanism of p53-dependent apoptosis is identified in which p 53-mediated up-regulation of MnSOD and GPx, but not CAT, produces an imbalance in antioxidant enzymes and oxidative stress.
Journal ArticleDOI
The balance between Cu,Zn-superoxide dismutase and catalase affects the sensitivity of mouse epidermal cells to oxidative stress.
Paul Amstad,Alexander V. Peskin,Girish M. Shah,Marc Edouard Mirault,Rémy Moret,Irene Zbinden,Peter Cerutti +6 more
TL;DR: Study of the individual roles and the interaction of Cu,Zn-superoxide dismutase (SOD) and catalase (CAT) in transfectants with human cDNAs of mouse epidermal cells JB6 clone 41 finds that the effect of oxidants on cells is modulated by multiple interacting antioxidant defense systems.
Journal Article
Mechanism of c-fos induction by active oxygen.
TL;DR: It is proposed that poly-ADP-ribosylation is required because it participates in the repair of DNA breaks which interfere with transcription, and observed that Fos protein is weakly poly- ADP- ribosylated in response to active oxygen.