Kevin Jooß

TL;DR: This review belongs to a series of regularly published articles, summarizing 248 articles covering the time between June 2016 and May 2018, and describes latest developments on hyphenation of CE with MS as well as instrumental developments such as two‐dimensional separation systems with MS detection.

TL;DR: Two-dimensional capillary zone electrophoresis mass spectrometry for the characterization of intact monoclonal antibody (mAb) charge variants has the potential to become a compelling tool for MS characterization of antibody variants separated in ESI-interfering electrolytes.

TL;DR: A multiple heart‐cut approach is presented expanding the previous single heart‐ cut concept resulting in a dramatical reduction of analysis time and is expected to be applicable in different bioanalytical fields, e.g. for the fast and information rich characterization of therapeutic antibodies.

TL;DR: The first on-line coupling of CZE with drift tube ion mobility-mass spectrometry (DTIM-MS) has been perfomed to further improve separation capabilities for the analysis of native and 8-aminopyrene-1,3,6-trisulfonic acid (APTS)-labeled N-glycans.

TL;DR: Nuc-MS as discussed by the authors quantified nucleosome co-occupancy of histone H3.3 with variant H2A.Z (sixfold over bulk) and the co-occurrence of oncogenic H3K27M with euchromatic marks.