M
Michael-Christopher Keogh
Researcher at Durham University
Publications - 69
Citations - 6278
Michael-Christopher Keogh is an academic researcher from Durham University. The author has contributed to research in topics: Chromatin & Histone. The author has an hindex of 26, co-authored 60 publications receiving 5534 citations. Previous affiliations of Michael-Christopher Keogh include Imperial College London & Harvard University.
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Journal ArticleDOI
Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex.
Michael-Christopher Keogh,Siavash K. Kurdistani,Stephanie A. Morris,Seong Hoon Ahn,Vladimir Podolny,Sean R. Collins,Maya Schuldiner,Kayu Chin,Thanuja Punna,Natalie J. Thompson,Charles Boone,Andrew Emili,Jonathan S. Weissman,Timothy P. Hughes,Brian D. Strahl,Michael Grunstein,Jack Greenblatt,Stephen Buratowski,Nevan J. Krogan +18 more
TL;DR: Ch Chromatin immunoprecipitation and biochemical experiments indicate that the chromodomain of Eaf3 recruits Rpd3C(S) to nucleosomes methylated by Set2 on histone H3 lysine 36, leading to deacetylation of transcribed regions.
Journal ArticleDOI
A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1.
Nevan J. Krogan,Michael-Christopher Keogh,Nira Datta,Chika Sawa,Owen Ryan,Huiming Ding,Robin Haw,Jeffrey Pootoolal,Amy Hin Yan Tong,Veronica Canadien,Dawn Richards,Xiaorong Wu,Andrew Emili,Timothy P. Hughes,Stephen Buratowski,Jack Greenblatt +15 more
TL;DR: It is shown that recruitment of Htz1 to chromatin requires the SWR-C, a TFIID-interacting protein that recognizes acetylated histone tails that promotes gene expression near silent heterochromatin.
Journal ArticleDOI
A phosphatase complex that dephosphorylates γH2AX regulates DNA damage checkpoint recovery
Michael-Christopher Keogh,Jung-Ae Kim,Michael Downey,Jeffrey Fillingham,Dipanjan Chowdhury,Jacob C. Harrison,Megumi Onishi,Nira Datta,Sarah Galicia,Andrew Emili,Judy Lieberman,Xuetong Shen,Stephen Buratowski,James E. Haber,Daniel Durocher,Jack Greenblatt,Nevan J. Krogan,Nevan J. Krogan +17 more
TL;DR: A three-protein complex containing the phosphatase Pph3 that regulates the phosphorylation status of γH2AX in vivo and efficiently dephosphorylatesγH 2AX in vitro is described.
Journal ArticleDOI
γ-H2AX Dephosphorylation by Protein Phosphatase 2A Facilitates DNA Double-Strand Break Repair
Dipanjan Chowdhury,Michael-Christopher Keogh,Haruhiko Ishii,Craig L. Peterson,Stephen Buratowski,Judy Lieberman +5 more
TL;DR: It is shown that protein phosphatase 2A (PP2A) is involved in removing gamma-H2AX foci from chromatin and the effect of PP2A on gamma- H2AX levels is independent of ATM, ATR, or DNA-PK activity.
Journal ArticleDOI
Rewiring of genetic networks in response to DNA damage
Sourav Bandyopadhyay,Monika Mehta,Dwight Kuo,Min-Kyung Sung,Ryan Chuang,Eric J. Jaehnig,Bernd Bodenmiller,Katherine Licon,Wilbert Copeland,Michael Shales,Dorothea Fiedler,Dorothea Fiedler,Janusz Dutkowski,Aude Guénolé,Haico van Attikum,Kevan M. Shokat,Kevan M. Shokat,Richard D. Kolodner,Won-Ki Huh,Ruedi Aebersold,Michael-Christopher Keogh,Nevan J. Krogan,Trey Ideker +22 more
TL;DR: Using an approach called differential epistasis mapping, widespread changes in genetic interaction are discovered among yeast kinases, phosphatases, and transcription factors as the cell responds to DNA damage, uncovering many gene functions that go undetected in static conditions.