Marc A. Morgan

TL;DR: In this paper, the authors used chromatin immunoprecipitation-sequencing (ChIP-seq) to find that the Trithorax-related (Trr) branch of the COMPASS family regulates enhancer activity and is responsible for the implementation of H3K4me1 at these regions.

TL;DR: To examine the therapeutic potential of blocking the recruitment of bromodomain proteins by heterotypic H3K27M-K27ac nucleosomes in DIPG cells, treatments in vivo with BET bromidomain inhibitors are performed and demonstrate that they efficiently inhibit tumor progression, thus identifying this class of compounds as potential therapeutics in DipG.

TL;DR: Recent progress relating to the catalytic and non-catalytic functions of the Trithorax-COMPASS complexes, Polycomb repressive complexes and Clr4/Suv39 histone-modifying machineries are focused on.

TL;DR: The identification of the Mll2 complex as the COMPASS family member responsible for H3K4me3 marking bivalently marked promoters in embryonic stem cells provides an opportunity to reevaluate and experimentally test models for the function of bivalency in the embryonic stem cell state and in differentiation.

TL;DR: It is demonstrated that Drosophila embryos expressing catalytically deficient Trr eclose and develop to productive adulthood and point to a possible role for H3K4me1 on cis-regulatory elements in specific settings to fine-tune transcriptional regulation in response to environmental stress.