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Kevin Sinchak
Researcher at California State University, Long Beach
Publications - 44
Citations - 2441
Kevin Sinchak is an academic researcher from California State University, Long Beach. The author has contributed to research in topics: Hypothalamus & Estrogen. The author has an hindex of 25, co-authored 44 publications receiving 2267 citations. Previous affiliations of Kevin Sinchak include University of California, Los Angeles & Michigan State University.
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Journal ArticleDOI
Direct Regulation of Adult Brain Function by the Male-Specific Factor SRY
Phoebe Dewing,Charleston W. K. Chiang,Kevin Sinchak,Helena Sim,Pierre-Olivier Fernagut,Sabine Kelly,Marie-Françoise Chesselet,Paul E. Micevych,Kenneth H. Albrecht,Vincent R. Harley,Eric Vilain +10 more
TL;DR: It is demonstrated that the Y chromosome-linked, male-determining gene Sry is specifically expressed in the substantia nigra of the adult male rodent in tyrosine hydroxylase-expressing neurons.
Journal ArticleDOI
Membrane Estrogen Receptor-α Interactions with Metabotropic Glutamate Receptor 1a Modulate Female Sexual Receptivity in Rats
Phoebe Dewing,Marissa I. Boulware,Kevin Sinchak,Kevin Sinchak,Amy Christensen,Paul G. Mermelstein,Paul E. Micevych +6 more
TL;DR: Data is presented that shows that ERα and mGluR1a directly interact to mediate a rapid estradiol-induced activation of MOR in the medial preoptic nucleus, leading to female sexual receptivity, demonstrating the physiological importance of ERα-to-mGlu R1a signaling.
Journal ArticleDOI
Progesterone blockade of estrogen activation of mu-opioid receptors regulates reproductive behavior.
Kevin Sinchak,Paul E. Micevych +1 more
TL;DR: A central role is indicated in the mediation of sex steroid activation of the CNS to regulate female reproductive behavior through internalization of the μ-opioid receptor.
Journal ArticleDOI
The luteinizing hormone surge is preceded by an estrogen-induced increase of hypothalamic progesterone in ovariectomized and adrenalectomized rats.
TL;DR: It is suggested that estrogen enhances neuroprogesterone synthesis in the hypothalamus that is involved in the positive feedback regulating the LH surge, which is dependent on the pre-LH surge synthesis of progesterone.
Journal ArticleDOI
Estradiol stimulates progesterone synthesis in hypothalamic astrocyte cultures.
TL;DR: The present results are consistent with the hypothesis that estrogen-positive feedback regulating the LH surge involves stimulating local progesterone synthesis by hypothalamic astrocytes, and indicate that estradiol acts through a membrane-associated receptor to release intracellular stores of Ca(2+).