K
Kevork Hagopian
Researcher at University of California, Davis
Publications - 44
Citations - 2123
Kevork Hagopian is an academic researcher from University of California, Davis. The author has contributed to research in topics: Calorie restriction & Oxidative stress. The author has an hindex of 23, co-authored 44 publications receiving 1917 citations. Previous affiliations of Kevork Hagopian include University of London & Wayne State University.
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Journal ArticleDOI
A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice.
Megan N. Roberts,Marita A. Wallace,Alexey Tomilov,Zeyu Zhou,George R. Marcotte,Dianna Tran,Gabriella Perez,Elena Gutiérrez-Casado,Shinichiro Koike,Trina A. Knotts,Denise M. Imai,Stephen M Griffey,Kyoungmi Kim,Kevork Hagopian,Marissa Z. McMackin,Fawaz G. Haj,Keith Baar,Gino A Cortopassi,Jon J. Ramsey,Jose Alberto Lopez-Dominguez +19 more
TL;DR: It is demonstrated that a KD extends longevity and healthspan in mice and regulated mTORC1 signaling in a tissue-dependent manner.
Journal ArticleDOI
Ageing, oxidative stress, and mitochondrial uncoupling
TL;DR: Emphasis is placed upon the roles of mitochondrial proton leak, the uncoupling proteins, and the anti-ageing effects of caloric restriction in the effects of oxidative stress and ageing on mitochondrial function.
Journal ArticleDOI
Effects of short- and medium-term calorie restriction on muscle mitochondrial proton leak and reactive oxygen species production
TL;DR: Results indicate that a reduction in mitochondrial Vo2 and ROS production may be a mechanism for the actions of CR.
Journal ArticleDOI
Long-term caloric restriction increases UCP3 content but decreases proton leak and reactive oxygen species production in rat skeletal muscle mitochondria.
Lisa Bevilacqua,Jon J. Ramsey,Kevork Hagopian,Richard Weindruch,Richard Weindruch,Mary-Ellen Harper +5 more
TL;DR: Mitochondrial H2O2 production and oxidative damage were decreased by CR at both time points and increased with age, and Muscle UCP3 protein content increased with long-term CR, consistent with a role in protection from ROS but inconsistent with the observed decrease or no change in proton leak.
Journal ArticleDOI
Caloric restriction increases gluconeogenic and transaminase enzyme activities in mouse liver.
TL;DR: Investigation of the activities of gluconeogenic and transaminase enzymes in the livers of old and young mice fed either control or calorie-restricted diets demonstrates increased gluc oneogenic activity in CR mice, consistent with a state of increased hepatic gluconeogenesis and protein turnover during CR.