S
Shinichiro Koike
Researcher at University of California, Davis
Publications - 12
Citations - 421
Shinichiro Koike is an academic researcher from University of California, Davis. The author has contributed to research in topics: Epoxide hydrolase 2 & Medicine. The author has an hindex of 6, co-authored 8 publications receiving 277 citations.
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Journal ArticleDOI
A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice.
Megan N. Roberts,Marita A. Wallace,Alexey Tomilov,Zeyu Zhou,George R. Marcotte,Dianna Tran,Gabriella Perez,Elena Gutiérrez-Casado,Shinichiro Koike,Trina A. Knotts,Denise M. Imai,Stephen M Griffey,Kyoungmi Kim,Kevork Hagopian,Marissa Z. McMackin,Fawaz G. Haj,Keith Baar,Gino A Cortopassi,Jon J. Ramsey,Jose Alberto Lopez-Dominguez +19 more
TL;DR: It is demonstrated that a KD extends longevity and healthspan in mice and regulated mTORC1 signaling in a tissue-dependent manner.
Journal ArticleDOI
Protein tyrosine phosphatase 1B deficiency in podocytes mitigates hyperglycemia-induced renal injury.
Yoshihiro Ito,Ming-Fo Hsu,Ahmed Bettaieb,Shinichiro Koike,A. F. S. Mello,Miguel Calvo-Rubio,José M. Villalba,Fawaz G. Haj +7 more
TL;DR: Findings demonstrate that podocyte PTP1B deficiency attenuates hyperglycemia-induced renal damage and suggest that PTP2B may present a therapeutic target in renal injury and demonstrates that pharmacological attenuation of autophagy in P TP1B knockdown podocytes mitigated the protective effects of PTP 1B deficiency.
Journal ArticleDOI
Podocyte-specific soluble epoxide hydrolase deficiency in mice attenuates acute kidney injury.
Ahmed Bettaieb,Ahmed Bettaieb,Shinichiro Koike,Samah Chahed,Yi Zhao,Santana Bachaalany,Nader Hashoush,James L. Graham,Huma Fatima,Peter J. Havel,Artiom Gruzdev,Darryl C. Zeldin,Bruce D. Hammock,Fawaz G. Haj +13 more
TL;DR: Findings identify sEH in podocytes as a contributor to signaling events in acute renal injury and suggest that sEH inhibition may be of therapeutic value in proteinuria.
Journal ArticleDOI
Soluble epoxide hydrolase in podocytes is a significant contributor to renal function under hyperglycemia.
Ahmed Bettaieb,Shinichiro Koike,Ming-Fo Hsu,Yoshihiro Ito,Samah Chahed,Santana Bachaalany,Artiom Gruzdev,Miguel Calvo-Rubio,Kin Sing Stephen Lee,Bora Inceoglu,John D. Imig,José M. Villalba,Darryl C. Zeldin,Bruce D. Hammock,Fawaz G. Haj +14 more
TL;DR: Findings establish sEH in podocytes as a significant contributor to renal function under hyperglycemia and suggest that sEH is a potential therapeutic target for podocytopathies.
Journal ArticleDOI
Hepatic protein-tyrosine phosphatase 1B disruption and pharmacological inhibition attenuate ethanol-induced oxidative stress and ameliorate alcoholic liver disease in mice.
TL;DR: Findings causally link hepatic PTP1B and ALD and define a potential therapeutic target for the management of this disease.