다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

Tissue engineering (TE) and regenerative medicine integrate information and technology from various fields to restore/replace tissues and damaged organs for medical treatments. To achieve this, scaffolds act as delivery vectors or as cellular systems for drugs and cells; thereby, cellular material is able to colonize host cells sufficiently to meet up the requirements of regeneration and repair. This process is multi-stage and requires the development of various components to create the desired neo-tissue or organ. In several current TE strategies, biomaterials are essential components. While several polymers are established for their use as biomaterials, careful consideration of the cellular environment and interactions needed is required in selecting a polymer for a given application. Depending on this, scaffold materials can be of natural or synthetic origin, degradable or nondegradable. In this review, an overview of various natural and synthetic polymers and their possible composite scaffolds with their physicochemical properties including biocompatibility, biodegradability, morphology, mechanical strength, pore size, and porosity are discussed. The scaffolds fabrication techniques and a few commercially available biopolymers are also tabulated.

A Comparative Review of Natural and Synthetic Biopolymer Composite Scaffolds.

Phytosterols and their derivatives: Structural diversity, distribution, metabolism, analysis, and health-promoting uses.

In the effort toward sustainable advanced functional materials, nanocelluloses have attracted extensive recent attention. Nanocelluloses range from rod-like highly crystalline cellulose nanocrystals to longer and more entangled cellulose nanofibers, earlier denoted also as microfibrillated celluloses and bacterial cellulose. In recent years, they have spurred research toward a wide range of applications, ranging from nanocomposites, viscosity modifiers, films, barrier layers, fibers, structural color, gels, aerogels and foams, and energy applications, until filtering membranes, to name a few. Still, nanocelluloses continue to show surprisingly high challenges to master their interactions and tailorability to allow well-controlled assemblies for functional materials. Rather than trying to review the already extensive nanocellulose literature at large, here selected aspects of the recent progress are the focus. Water interactions, which are central for processing for the functional properties, are discussed first. Then advanced hybrid gels toward (multi)stimuli responses, shape-memory materials, self-healing, adhesion and gluing, biological scaffolding, and forensic applications are discussed. Finally, composite fibers are discussed, as well as nanocellulose as a strategy for improvement of photosynthesis-based chemicals production. In summary, selected perspectives toward new directions for sustainable high-tech functional materials science based on nanocelluloses are described.

https://www.onlinelibrary.wiley.com/doi/pdf/10.1002/adma.202004349

Nanocellulose: Recent Fundamental Advances and Emerging Biological and Biomimicking Applications.

The drug delivery system enables the release of the active pharmaceutical ingredient to achieve a desired therapeutic response. Conventional drug delivery systems (tablets, capsules, syrups, ointments, etc.) suffer from poor bioavailability and fluctuations in plasma drug level and are unable to achieve sustained release. Without an efficient delivery mechanism, the whole therapeutic process can be rendered useless. Moreover, the drug has to be delivered at a specified controlled rate and at the target site as precisely as possible to achieve maximum efficacy and safety. Controlled drug delivery systems are developed to combat the problems associated with conventional drug delivery. There has been a tremendous evolution in controlled drug delivery systems from the past two decades ranging from macro scale and nano scale to intelligent targeted delivery. The initial part of this review provides a basic understanding of drug delivery systems with an emphasis on the pharmacokinetics of the drug. It also discusses the conventional drug delivery systems and their limitations. Further, controlled drug delivery systems are discussed in detail with the design considerations, classifications and drawings. In addition, nano-drug delivery, targeted and smart drug delivery using stimuli-responsive and intelligent biomaterials is discussed with recent key findings. The paper concludes with the challenges faced and future directions in controlled drug delivery.

Controlled Drug Delivery Systems: Current Status and Future Directions.

3D-printed bioactive and biodegradable hydrogel scaffolds of alginate/gelatin/cellulose nanocrystals for tissue engineering.

Bioactive electrospun nanocomposite scaffolds of poly(lactic acid)/cellulose nanocrystals for bone tissue engineering.

Nanocellulose, a versatile platform: From the delivery of active molecules to tissue engineering applications.

Carbon nanotubes (CNTs) are considered a promising nanomaterial for diverse applications owing to their attractive physicochemical properties such as high surface area, superior mechanical and thermal strength, electrochemical activity, and so on. Different techniques like arc discharge, laser vaporization, chemical vapor deposition (CVD), and vapor phase growth are explored for the synthesis of CNTs. Each technique has advantages and disadvantages. The physicochemical properties of the synthesized CNTs are profoundly affected by the techniques used in the synthesis process. Here, we briefly described the standard methods applied in the synthesis of CNTs and their use in the agricultural and biotechnological fields. Notably, better seed germination or plant growth was noted in the presence of CNTs than the control. However, the exact mechanism of action is still unclear. Significant improvements in the electrochemical performances have been observed in CNTs-doped electrodes than those of pure. CNTs or their derivatives are also utilized in wastewater treatment. The high surface area and the presence of different functional groups in the functionalized CNTs facilitate the better adsorption of toxic metal ions or other chemical moieties. CNTs or their derivatives can be applied for the storage of hydrogen as an energy source. It has been observed that the temperature widely influences the hydrogen storage ability of CNTs. This review paper highlighted some recent development on electrochemical platforms over single-walled CNTs (SWCNTs), multi-walled CNTs (MWCNTs), and nanocomposites as a promising biomaterial in the field of agriculture and biotechnology. It is possible to tune the properties of carbon-based nanomaterials by functionalization of their structure to use as an engineering toolkit for different applications, including agricultural and biotechnological fields.

/pdf/carbon-nanotubes-based-nanomaterials-and-their-agricultural-592pd1i8br.pdf

Keya Ganguly

Papers

3D-printed bioactive and biodegradable hydrogel scaffolds of alginate/gelatin/cellulose nanocrystals for tissue engineering.

Bioactive electrospun nanocomposite scaffolds of poly(lactic acid)/cellulose nanocrystals for bone tissue engineering.

Nanocellulose, a versatile platform: From the delivery of active molecules to tissue engineering applications.

Carbon Nanotubes-Based Nanomaterials and Their Agricultural and Biotechnological Applications.

Multifunctional bioactive chitosan/cellulose nanocrystal scaffolds eradicate bacterial growth and sustain drug delivery.