Keyi Fu

TL;DR: In this paper , the authors summarized achievements in delivery systems and contraceptive antigens in oral immunocontraceptive vaccines and explored the potential barriers for future vaccine design and application, including biological and physicochemical barriers of the gastrointestinal tract, mucosal tolerance, preexisting immunity, antigen residence time in the small intestine, species specificity and other safety issues.

TL;DR: Wang et al. as discussed by the authors found that phenylpropanoid biosynthesis, phenylalanine, tyrosine and tryptophan metabolism related to the biosynthesis of flavonoids were upregulated in the high altitude group, which may enhance the environmental adaptability to strong ultraviolet intensity and low temperature stress in high altitude areas.

TL;DR: The authors showed that swainsonine significantly upregulated the levels of deoxycholic acid and taurine-β-muricholic acid in the serum and liver of mice due to the markedly increased genus Clostridium and decreased genus Lactobacillus in the gut.

TL;DR: In this paper , the authors used machine learning algorithms (random forest) to identify five biomarkers of serum metabolites indicative of the altitude, i.e., dihydrotestosterone, homo-Larginine, alpha-ketoglutaric acid, serotonin and threonine, which were related to body weight, reproduction, and energy metabolism of pika.

TL;DR: In this article , the authors showed that SH8 isolated from a polluted lake could interact with Synechocystis sp. PCC6803, a model species of cyanobacteria, in strengthening Cd2+ toxicity resistance.