K
Khajamohiddin Syed
Researcher at University of Zululand
Publications - 52
Citations - 3982
Khajamohiddin Syed is an academic researcher from University of Zululand. The author has contributed to research in topics: Phanerochaete & Gene. The author has an hindex of 20, co-authored 47 publications receiving 3159 citations. Previous affiliations of Khajamohiddin Syed include University of Cincinnati Academic Health Center & University of Cincinnati.
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Journal ArticleDOI
Molecular evolutionary dynamics of cytochrome P450 monooxygenases across kingdoms: Special focus on mycobacterial P450s
Mohammad Parvez,Lehlohonolo Benedict Qhanya,Ntsane Trevor Mthakathi,Ipeleng Kopano Rosinah Kgosiemang,Hans Denis Bamal,Nataraj Sekhar Pagadala,Ting Xie,Haoran Yang,Hengye Chen,Chrispian W. Theron,Richie Monyaki,Seiso Caiphus Raselemane,Vuyani Salewe,Bogadi Lorato Mongale,Retshedisitswe Godfrey Matowane,Sara Mohamed Hasaan Abdalla,Wool Isaac Booi,Mari van Wyk,Dedré Olivier,Charlotte E. Boucher,David R. Nelson,Jack A. Tuszynski,Jonathan M. Blackburn,Jae-Hyuk Yu,Samson Sitheni Mashele,Wanping Chen,Khajamohiddin Syed +26 more
TL;DR: Phylogenetic and functional analyses revealed the functional conservation of P450s despite belonging to different biological kingdoms, suggesting the adherence of P 450s to their innate function such as their involvement in either generation or oxidation of steroids and structurally related molecules, fatty acids and terpenoids.
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Cytochrome P450 Monooxygenase CYP53 Family in Fungi: Comparative Structural and Evolutionary Analysis and Its Role as a Common Alternative Anti-Fungal Drug Target
Poojah Jawallapersand,Samson Sitheni Mashele,Lidija Kovačič,Jure Stojan,Radovan Komel,Suresh B. Pakala,Nada Kraševec,Khajamohiddin Syed +7 more
TL;DR: Functional analysis of CYP53 P450s strongly supported the hypothesis that the ascomycetes CYP 53 P 450s ability is limited for detoxification of toxic molecules, whereas basidiomycete CYP43 P450S play an additional role, i.e. involvement in degradation of wood and its derived components.
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Comparative analysis of P450 signature motifs EXXR and CXG in the large and diverse kingdom of fungi: identification of evolutionarily conserved amino acid patterns characteristic of P450 family.
TL;DR: Analysis of 67 P450 families from biological kingdoms showed conservation of a set of amino acid patterns characteristic of a particular P450 family in EXXR and CXG motifs, which suggests that during the divergence of P 450 families from a common ancestor these amino acids patterns evolve and are retained in each P 450 family as a signature of that family.
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A Fungal P450 (CYP5136A3) Capable of Oxidizing Polycyclic Aromatic Hydrocarbons and Endocrine Disrupting Alkylphenols: Role of Trp129 and Leu324
TL;DR: This is the first report on an AP-oxidizing P450 from fungi and on structure-activity relationship of a eukaryotic P450 for fused-ring PAHs (phenanthrene and pyrene) and AP substrates and suggests that Trp129 and Leu324 are critical in substrate recognition and/or regio-selective oxidation ofPAHs and APs.
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A novel P450-initiated biphasic process for sustainable biodegradation of benzo[a]pyrene in soil under nutrient-sufficient conditions by the white rot fungus Phanerochaete chrysosporium.
TL;DR: This study reports development of an alternative novel biphasic process initiated under nutrient-sufficient (non-ligninolytic) culture conditions, by employing an advanced experimental design strategy yielding improved sustainable bioremediation of PAH-contaminated soil.