Kien Thi Hue Duong

TL;DR: Although this trial, the first of its kind in dengue, does not support balapiravir as a candidate drug, it does establish a framework for antiviral treatment trials in d Dengue and provides the field with a clinically evaluated benchmark molecule.

TL;DR: A nested case-control comparison of the early host transcriptional features in 24 DSS patients and 56 sex-, age-, and virus serotype-matched uncomplicated dengue patients suggests a hitherto unrecognized association between neutrophil activation, pathogenesis, and the development of DSS.

TL;DR: A novel virus neutralization assay was developed, employing Aedes aegypti mosquitoes and viremic blood from dengue patients, to examine the virus-neutralizing potency of 12 human-derived monoclonal antibodies (mAbs), and found the mAb accelerated the reduction of viremia.

TL;DR: It is demonstrated that mAbs can neutralize infectious DENV derived from infected human cells, in the matrix of human blood, coupled with previous evidence of their ability to prevent DENV infection of mammalian cells.

TL;DR: In this article , the authors used phylogenetic methods to infer the probable route of virus introductions into HCMC and its surrounding areas, as well as their approximate timing, using additional sequences from Southern and South-east Asia.