H
Hien Tinh Tran
Researcher at University of Oxford
Publications - 12
Citations - 1694
Hien Tinh Tran is an academic researcher from University of Oxford. The author has contributed to research in topics: Dengue fever & Plasmodium vivax. The author has an hindex of 10, co-authored 11 publications receiving 1459 citations.
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Journal ArticleDOI
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
Olivo Miotto,Roberto Amato,Elizabeth A. Ashley,Bronwyn MacInnis,Jacob Almagro-Garcia,Chanaki Amaratunga,Pharath Lim,Daniel Mead,Samuel O. Oyola,Mehul Dhorda,Mallika Imwong,Charles J. Woodrow,Magnus Manske,Jim Stalker,Eleanor Drury,Susana Campino,Lucas Amenga-Etego,Thanh T-Nn.,Hien Tinh Tran,Pascal Ringwald,Delia Bethell,François Nosten,Aung Pyae Phyo,S Pukrittayakamee,Kesinee Chotivanich,Char Meng Chuor,Chea Nguon,Seila Suon,Sokunthea Sreng,Paul N. Newton,Mayfong Mayxay,Maniphone Khanthavong,Bouasy Hongvanthong,Ye Htut,K T Han,Myat Phone Kyaw,MA Faiz,Caterina I. Fanello,M A Onyamboko,Olugbenga A. Mokuolu,Christopher G Jacob,Shannon Takala-Harrison,Christopher V. Plowe,Nicholas P. J. Day,Arjen M. Dondorp,Spencer Cca.,Gil McVean,Rick M. Fairhurst,Nicholas J. White,Dominic P. Kwiatkowski +49 more
TL;DR: Analysis of the fine structure of the parasite population showed that the fd, arps10, mdr2 and crt polymorphisms are markers of a genetic background on which kelch13 mutations are particularly likely to arise and that they correlate with the contemporary geographical boundaries and population frequencies of artemisinin resistance.
Journal ArticleDOI
A randomized controlled trial of chloroquine for the treatment of dengue in Vietnamese adults.
Vianney Tricou,Nguyet Nguyen Minh,Toi Pham Van,Sue J. Lee,Sue J. Lee,Jeremy Farrar,Jeremy Farrar,Bridget Wills,Bridget Wills,Hien Tinh Tran,Cameron P. Simmons,Cameron P. Simmons +11 more
TL;DR: CQ does not reduce the durations of viraemia and NS1 antigenaemia in dengue patients and was associated with significantly more adverse events, primarily vomiting.
Journal ArticleDOI
A Randomized, Double-Blind Placebo Controlled Trial of Balapiravir, a Polymerase Inhibitor, in Adult Dengue Patients
Nguyet Minh Nguyen,Chau Nguyen Bich Tran,Lam Khanh Phung,Kien Thi Hue Duong,Huy Le Anh Huynh,Jeremy Farrar,Quyen Nguyen,Hien Tinh Tran,Chau Van Vinh Nguyen,Laura Merson,Long T. Hoang,Martin L. Hibberd,Pauline P. K. Aw,Andreas Wilm,Niranjan Nagarajan,Dung Thi Nguyen,Mai Phuong Pham,Truong Thanh Nguyen,Hassan Javanbakht,Klaus Klumpp,Janet Hammond,Rosemary Petric,Marcel Wolbers,Chinh Nguyen,Cameron P. Simmons +24 more
TL;DR: Although this trial, the first of its kind in dengue, does not support balapiravir as a candidate drug, it does establish a framework for antiviral treatment trials in d Dengue and provides the field with a clinically evaluated benchmark molecule.
Journal ArticleDOI
Kinetics of Viremia and NS1 Antigenemia Are Shaped by Immune Status and Virus Serotype in Adults with Dengue
TL;DR: The findings suggest that the early magnitude of viremia is positively associated with disease severity, and the clearance of DENV is associated with immune status, and there are serotype dependent differences in infection kinetics.
Journal ArticleDOI
Comparison of two dengue NS1 rapid tests for sensitivity, specificity and relationship to viraemia and antibody responses
Vianney Tricou,Hang T T Vu,Nhu V N Quynh,Chau V V Nguyen,Hien Tinh Tran,Jeremy Farrar,Bridget Wills,Cameron P. Simmons +7 more
TL;DR: The data suggest that the NS1 test component of these assays are highly specific and have similar levels of sensitivity, and the IgM parameter in the SD Duo test improved overall test sensitivity without compromising specificity.