K
Kihoon Nam
Researcher at University of Utah
Publications - 52
Citations - 2582
Kihoon Nam is an academic researcher from University of Utah. The author has contributed to research in topics: Gene delivery & Transfection. The author has an hindex of 23, co-authored 49 publications receiving 2348 citations. Previous affiliations of Kihoon Nam include Seoul National University & Chungnam National University.
Papers
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Journal ArticleDOI
HMGB1, a novel cytokine-like mediator linking acute neuronal death and delayed neuroinflammation in the postischemic brain
Jung-Bin Kim,Joon Sig Choi,Young-Mi Yu,Kihoon Nam,Chun Shu Piao,Seung-Woo Kim,Minhyung Lee,Pyung-Lim Han,Jong-Sang Park,Ja-Kyeong Lee +9 more
TL;DR: It is demonstrated that high-mobility group box 1 (HMGB1), a nonhistone DNA-binding protein, is massively released into the extracellular space immediately after ischemic insult and that it subsequently induces neuroinflammation in the postischemic brain.
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Enhanced transfection efficiency of PAMAM dendrimer by surface modification with L-arginine.
TL;DR: The L-arginine-grafted-PAMAM dendrimer possesses the potential to be a novel gene delivery carrier for gene therapy, and the complex composed of PAMAM-Arg/DNA showed increased gene delivery potency compared to native P AMAM d endrimer and PAM AM-Lys.
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Biodegradable PAMAM ester for enhanced transfection efficiency with low cytotoxicity.
Hye Yeong Nam,Kihoon Nam,Hwa Jeong Hahn,Bo Hye Kim,Hyun-Jung Lim,Hyun-Jin Kim,Joon Sig Choi,Jong-Sang Park +7 more
TL;DR: It is demonstrated that the arginine-grafted biodegradable PAMAM dendrimer, e-PAM-R, is a potential candidate as a safe and efficient gene delivery carrier for gene therapy.
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Neuroprotection by biodegradable PAMAM ester (e-PAM-R)-mediated HMGB1 siRNA delivery in primary cortical cultures and in the postischemic brain
Il-Doo Kim,Chae-Moon Lim,Jung-Bin Kim,Hye Yeong Nam,Kihoon Nam,Seung Woo Kim,Jong-Sang Park,Ja-Kyeong Lee +7 more
TL;DR: Results indicate that e-PAM-R, a novel biodegradable nonviral gene carrier, offers an efficient means of transfecting siRNA into primary neuronal cells and in the brain and of performing siRNA-mediated gene knockdown.
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Enhanced transfection of primary cortical cultures using arginine-grafted PAMAM dendrimer, PAMAM-Arg.
TL;DR: Evidence is presented of the successful delivery and expression of both a reporter gene and of a shRNA-expressing plasmid in primary cortical cells, which demonstrates the potential of PAMAM-Arg for mediating gene delivery to primary neuronal cells.