Kim-Anne Lê

TL;DR: Although there is compelling evidence that very high fructose intake can have deleterious metabolic effects in humans as in rodents, the role of fructose in the development of the current epidemic of metabolic disorders remains controversial.

TL;DR: A 7-d high-fructose diet increased ectopic lipid deposition in liver and muscle and fasting VLDL-triacylglycerols and decreased hepatic insulin sensitivity in healthy offspring of patients with type 2 diabetes, suggesting that these individuals may be more prone to developing dyslipidemia when challenged by high fructose intakes.

TL;DR: In this paper, the effects of fructose, a potent stimulator of hepatic de novo lipogenesis, on intrahepatocellular lipids (IHCLs) and insulin sensitivity in healthy offspring of patients with type 2 diabetes (OffT2D), were assessed with a 2-step hyperinsulinemic euglycemic clamp.

TL;DR: Moderate fructose supplementation over 4 wk increases plasma triacylglycerol and glucose concentrations without causing ectopic lipid deposition or insulin resistance in healthy humans.

TL;DR: Consuming large amounts of fructose can lead to the development of a complete metabolic syndrome in rodents and in humans, fructose consumed in moderate to high quantities in the diet increases plasma triglycerides and alters hepatic glucose homeostasis, but does not appear to cause muscle insulin resistance or high blood pressure in the short term.