Kim S. C. Weber

TL;DR: JAM-1 is a counter-receptor for LFA-1 that is ideally situated to guide and control transmigration during leukocyte recruitment and is also a ligand of the β2 integrin lymphocyte function–associated antigen 1.

TL;DR: The deposition of RANTES by platelets triggers shear-resistant monocyte arrest on inflamed or atherosclerotic endothelium and may epitomize a novel principle relevant to inflammatory or atherogenic monocyte recruitment from the circulation.

TL;DR: The reduction ofCD11b expression and inhibition of CD11b-dependent monocyte adhesion to endothelium may crucially contribute to the clinical benefit of HMG-CoA reductase inhibitors in CHD, independent of cholesterol-lowering effects.

TL;DR: Flow cytometric analysis of isolated human monocytes recovered after transendothelial chemotaxis assays revealed that the percentage of CD14+CD16+ cells was dramatically reduced in the fraction migrating toward MCP‐1 compared with the fraction that did not migrate or the input, showing that polarized CCR2 expression was accompanied by a differential chemotactic responsiveness.

TL;DR: This is the first demonstration of endothelial CCR2 expression ex vivo, inferring its involvement in inflammatory conditions and may have important implications for endothelial wound repair and inflammatory reactions.