A
Alma Zernecke
Researcher at University of Würzburg
Publications - 137
Citations - 8547
Alma Zernecke is an academic researcher from University of Würzburg. The author has contributed to research in topics: Inflammation & Chemokine. The author has an hindex of 47, co-authored 137 publications receiving 6986 citations. Previous affiliations of Alma Zernecke include Technische Universität München & Ludwig Maximilian University of Munich.
Papers
More filters
Journal ArticleDOI
JAM-1 is a ligand of the beta(2) integrin LFA-1 involved in transendothelial migration of leukocytes.
Georg Ostermann,Kim S. C. Weber,Alma Zernecke,Andreas Schröder,Christian Weber,Christian Weber +5 more
TL;DR: JAM-1 is a counter-receptor for LFA-1 that is ideally situated to guide and control transmigration during leukocyte recruitment and is also a ligand of the β2 integrin lymphocyte function–associated antigen 1.
Journal ArticleDOI
Single-Cell RNA-Seq Reveals the Transcriptional Landscape and Heterogeneity of Aortic Macrophages in Murine Atherosclerosis
Clément Cochain,Ehsan Vafadarnejad,Panagiota Arampatzi,Jaroslav Pelisek,Holger Winkels,Klaus Ley,Dennis Wolf,Dennis Wolf,Antoine-Emmanuel Saliba,Alma Zernecke +9 more
TL;DR: Single-cell RNA sequencing unprecedentedly uncovered the transcriptional landscape and phenotypic heterogeneity of aortic macrophages and monocyte-derived dendritic cells in atherosclerotic arteries and identified previously unrecognized macrophage populations and their gene expression signature, suggesting specialized functions.
Journal ArticleDOI
Platelet Microparticles: A Transcellular Delivery System for RANTES Promoting Monocyte Recruitment on Endothelium
TL;DR: Circulating PMPs may serve as a finely tuned transcellular delivery system for RANTES, triggering monocyte arrest to inflamed and Atherosclerotic endothelium, introducing a novel mechanism for platelet-dependent monocyte recruitment in inflammation and atherosclerosis.
Journal ArticleDOI
Atlas of the Immune Cell Repertoire in Mouse Atherosclerosis Defined by Single-Cell RNA-Sequencing and Mass Cytometry
Holger Winkels,Erik Ehinger,Melanie Vassallo,Konrad Buscher,Huy Q. Dinh,Kouji Kobiyama,Anouk A.J. Hamers,Clément Cochain,Ehsan Vafadarnejad,Antoine-Emmanuel Saliba,Alma Zernecke,Akula Bala Pramod,Amlan K. Ghosh,Nathaly Anto Michel,Natalie Hoppe,Ingo Hilgendorf,Andreas Zirlik,Catherine C. Hedrick,Klaus Ley,Klaus Ley,Dennis Wolf +20 more
TL;DR: The definition of leukocyte diversity by high-dimensional analyses enables a fine-grained analysis of aorticLeukocyte subsets, reveals new immunologic mechanisms and cell-type–specific pathways, and establishes a functional relevance for lesional leukocytes in human atherosclerosis.
Journal ArticleDOI
Auto-Antigenic Protein-DNA Complexes Stimulate Plasmacytoid Dendritic Cells to Promote Atherosclerosis
Yvonne Döring,Helga D. Manthey,Maik Drechsler,Dirk Lievens,Remco T. A. Megens,Oliver Soehnlein,Martin Busch,Marco Manca,Rory R. Koenen,Jaroslav Pelisek,Mat J.A.P. Daemen,Esther Lutgens,Martin Zenke,Christoph J. Binder,Christian Weber,Alma Zernecke +15 more
TL;DR: Self-DNA released from dying cells or in neutrophil extracellular traps and an increased expression of the antimicrobial peptide Cramp/LL37 in atherosclerotic lesions may stimulate a pDC-driven pathway of autoimmune activation and the generation of anti–double-stranded-DNA antibodies, critically aggravating atherosclerosis lesion formation.