K
Kimberly A. Dooley
Researcher at University of California, Irvine
Publications - 3
Citations - 395
Kimberly A. Dooley is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Sterol regulatory element-binding protein & Promoter. The author has an hindex of 3, co-authored 3 publications receiving 383 citations.
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Sterol regulation of 3-hydroxy-3-methylglutaryl-coenzyme A synthase gene through a direct interaction between sterol regulatory element binding protein and the trimeric CCAAT-binding factor/nuclear factor Y
TL;DR: CCAAT binding factor/nuclear factor Y (CBF/NF-Y) binding to the CCAAT box is required for sterol-regulated transcription of HMG-CoA synthase, and it is shown that increasing this distance results in a decrease in the level of transcriptional regulation by sterols.
Journal ArticleDOI
Sterol regulation of acetyl coenzyme A carboxylase promoter requires two interdependent binding sites for sterol regulatory element binding proteins
TL;DR: There are two distinct sites for SREBP binding that control activation of the ACC PII promoter whereas previous work has shown there is only a single SRE BP site in the LDL receptor, and the two sites are equally important and dependent on one another for optimal function.
Journal ArticleDOI
A Critical Role for cAMP Response Element-binding Protein (CREB) as a Co-activator in Sterol-regulated Transcription of 3-Hydroxy-3-methylglutaryl Coenzyme A Synthase Promoter
TL;DR: This is the first promoter shown to require CREB for efficient sterol-regulated transcription, and to require two different co-regulatory factors in addition to SREBPs for maximal activation.