K
Kimberly M. Newkirk
Researcher at University of Tennessee
Publications - 26
Citations - 726
Kimberly M. Newkirk is an academic researcher from University of Tennessee. The author has contributed to research in topics: Medicine & Slug. The author has an hindex of 13, co-authored 19 publications receiving 671 citations. Previous affiliations of Kimberly M. Newkirk include Ohio State University.
Papers
More filters
Journal ArticleDOI
Ultraviolet Radiation-Induced Corneal Degeneration in 129 Mice:
Kimberly M. Newkirk,Heather L. Chandler,Allison E. Parent,Donn C. Young,Carmen M. H. Colitz,David A. Wilkie,Donna F. Kusewitt +6 more
TL;DR: It is proposed that the loss of keratocytes observed in the chronic study was due to UVR-induced apoptosis, and this is the first report of the occurrence of spontaneous cataracts in 129 mice.
Journal ArticleDOI
Cutaneous wound reepithelialization is compromised in mice lacking functional Slug (Snai2)
Laurie G. Hudson,Kimberly M. Newkirk,Heather L. Chandler,Changsun Choi,Stacey L. Fossey,Allison E. Parent,Donna F. Kusewitt +6 more
TL;DR: In this article, an in-vivo validation of the role of Slug (Snai2) in wound healing was conducted in 20 Slug null and 20 wild type mice exposed three times weekly to two minimal erythemal doses of UVR, the development of non-healing cutaneous ulcers was documented.
Journal ArticleDOI
Slug/Snai2 is a downstream mediator of epidermal growth factor receptor-stimulated reepithelialization.
D.F. Kusewitt,Changsun Choi,Kimberly M. Newkirk,Pascale Leroy,Yafan Li,Miquella Chavez,Laurie G. Hudson +6 more
TL;DR: In this article, it was shown that Slug expression is necessary for an EGFR-stimulated wound reepithelialization response and that the response to EGFR activation is more robust than to other receptor tyrosine kinase ligands.
Journal ArticleDOI
Ultraviolet Radiation Stimulates Expression of Snail Family Transcription Factors in Keratinocytes
Laurie G. Hudson,Changsun Choi,Kimberly M. Newkirk,Jaipriya Parkhani,Karen L. Cooper,Ping Lu,Donna F. Kusewitt +6 more
TL;DR: It is reported here that ultraviolet radiation (UVR), which activates MAPK cascades, also stimulates Snail and Slug expression in epidermal keratinocytes, and Slug appears to play a functional role in the acute response of keratinocyte response to UVR.
Journal ArticleDOI
Detection of human papillomavirus DNA in feline premalignant and invasive squamous cell carcinoma
Sarah H. O’Neill,Kimberly M. Newkirk,Eman Anis,Rupal A. Brahmbhatt,Linda A. Frank,Stephen A. Kania +5 more
TL;DR: The results of this study suggest that in the cat, HPV DNA may be detectible within a higher percentage of squamous lesions than previously demonstrated, UV exposure may not be a confounder for PV presence, and noncutaneous lesions may have a low prevalence of PV.