Kiminori Hosoda

TL;DR: Evidence is provided that ghrelin is an orexigenic peptide that antagonizes leptin action through the activation of hypothalamic NPY/Y1 receptor pathway and is effective in growth hormone-deficient spontaneous dwarf rats.

TL;DR: It is reported that forced expression of either Gata-6 or Gata -4 in embryonic stem (ES) cells is sufficient to induce the proper differentiation program towards ExE, the first report of a physiological differentiation event induced by the ectopic expression of a transcription factor in ES cells.

TL;DR: BP elevation is demonstrated in transgenic skinny mice and obese KKA(y) mice that are both hyperleptinemic, thereby suggesting the pathophysiological role of leptin in some forms of obesity-related hypertension.

TL;DR: It is demonstrated that the kidney, glomerulus and renal cells express prepro‐ghrelin gene and ghrelin is produced locally in the kidney and suggested the endocrine and/or paracrine roles of gh Relin in the kidneys.

TL;DR: It is demonstrated that leptin can improve the insulin resistance and diabetes of a mouse model of severe lipoatrophic diabetes, suggesting that leptin may be therapeutically useful in the long-term treatment of lipoatrophe diabetes.