H
Hiroshi Hosoda
Researcher at Kyoto University
Publications - 211
Citations - 28277
Hiroshi Hosoda is an academic researcher from Kyoto University. The author has contributed to research in topics: Ghrelin & Ghrelin secretion. The author has an hindex of 64, co-authored 203 publications receiving 26967 citations.
Papers
More filters
Journal ArticleDOI
Ghrelin is a growth-hormone-releasing acylated peptide from stomach.
TL;DR: The occurrence of ghrelin in both rat and human indicates that GH release from the pituitary may be regulated not only by hypothalamic GHRH, but also by ghrelIn, a peptide specifically releases GH both in vivo and in vitro.
Journal ArticleDOI
Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans.
Yukari Date,Masayasu Kojima,Hiroshi Hosoda,Akira Sawaguchi,Muhtashan S. Mondal,Tatsuo Suganuma,Shigeru Matsukura,Kenji Kangawa,Masamitsu Nakazato +8 more
TL;DR: Ghrelin probably functions not only in the control of GH secretion, but also in the regulation of diverse processes of the digestive system, and its findings provide clues to additional physiological functions of this novel gastrointestinal hormone.
Journal ArticleDOI
Stomach Is a Major Source of Circulating Ghrelin, and Feeding State Determines Plasma Ghrelin-Like Immunoreactivity Levels in Humans
Hiroyuki Ariyasu,Kazuhiko Takaya,Tetsuya Tagami,Yoshihiro Ogawa,Kiminori Hosoda,Takashi Akamizu,Michio Suda,Toshikiyo Koh,Koshi Natsui,Shigetake Toyooka,Gotaro Shirakami,Takeshi Usui,Akira Shimatsu,Kentaro Doi,Hiroshi Hosoda,Masayasu Kojima,Kenji Kangawa,Kazuwa Nakao +17 more
TL;DR: It is concluded that the stomach is a major source of circulating ghrelin and that plasma gh Relin-like immunoreactivity levels reflect acute and chronic feeding states in humans.
Journal ArticleDOI
Plasma Ghrelin Levels in Lean and Obese Humans and the Effect of Glucose on Ghrelin Secretion
Tomomi Shiiya,Masamitsu Nakazato,Masanari Mizuta,Yukari Date,Muhtashan S. Mondal,Muneki Tanaka,Shin-ichi Nozoe,Hiroshi Hosoda,Kenji Kangawa,Shigeru Matsukura +9 more
TL;DR: It is demonstrated that nutritional state is a determinant of plasma ghrelin in humans andGhrelin secretion is up-regulated under conditions of negative energy balance and down-regulated in the setting of positive energy balance, suggesting the involvement of gh Relin in the regulation of feeding behavior and energy homeostasis.
Journal ArticleDOI
Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue.
TL;DR: While gh Relin activates growth-hormone secretagogue (GHS) receptor-expressing cells, the nonmodified des-n-octanyl form of ghrelin, designated as des-acyl ghrel in, does not.