K
Kiriko Kaneko
Researcher at Tohoku University
Publications - 20
Citations - 701
Kiriko Kaneko is an academic researcher from Tohoku University. The author has contributed to research in topics: Renin–angiotensin system & Heme. The author has an hindex of 13, co-authored 20 publications receiving 624 citations. Previous affiliations of Kiriko Kaneko include Iwate Medical University.
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Journal ArticleDOI
Heme as a magnificent molecule with multiple missions: heme determines its own fate and governs cellular homeostasis.
TL;DR: The pleiotropic effects of hee on various biological events and the regulatory network of heme biosynthesis and catabolism are summarized and updated.
Journal ArticleDOI
Novel Mechanisms for Heme-dependent Degradation of ALAS1 Protein as a Component of Negative Feedback Regulation of Heme Biosynthesis
TL;DR: Evidence is provided that the mitochondrial ATP-dependent protease ClpXP, which is a heteromultimer of CLPX and CLPP, is involved in the heme-dependent degradation of ALAS1 in mitochondria and that ALAS 1 undergoes a conformational change following the association of heme to the heME-binding motif on this protein.
Journal ArticleDOI
Identification of a novel erythroid-specific enhancer for the ALAS2 gene and its loss-of-function mutation which is associated with congenital sideroblastic anemia.
Kiriko Kaneko,Kazumichi Furuyama,Kazumichi Furuyama,Tohru Fujiwara,Ryoji Kobayashi,Hiroyuki Ishida,Hideo Harigae,Shigeki Shibahara +7 more
TL;DR: It is proposed that the 130-base pair enhancer region located in the first intron of the ALAS2 gene should be examined in patients with congenital sideroblastic anemia in whom the gene responsible is unknown.
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Expression of (pro)renin receptor in human kidneys with end-stage kidney disease due to diabetic nephropathy
Kazuhiro Takahashi,Hajime Yamamoto,Hajime Yamamoto,Takuo Hirose,Keisuke Hiraishi,Itaru Shoji,Akiko Shibasaki,Ichiro Kato,Kiriko Kaneko,Hironobu Sasano,Fumitoshi Satoh,Kazuhito Totsune,Kazuhito Totsune +12 more
TL;DR: The possibility that (P)RR expressed in the diabetic kidney may play a pathophysiological role in angiotensin I generation and renal fibrosis found in end-stage renal disease is raised.
Journal ArticleDOI
Expression of (pro)renin receptor in the human brain and pituitary, and co-localisation with arginine vasopressin and oxytocin in the hypothalamus.
Kazuhiro Takahashi,Keisuke Hiraishi,Takuo Hirose,Ichiro Kato,Hajime Yamamoto,Hajime Yamamoto,Itaru Shoji,Akiko Shibasaki,Kiriko Kaneko,Fumitoshi Satoh,Kazuhito Totsune,Kazuhito Totsune +11 more
TL;DR: It is shown that (P)RR mRNA is widely expressed in the human brain and pituitary, consistent with the hypothesis that ( P)RR is related to the various brain functions, such as cognitive function and brain development.