K
Kirsten C. Verhein
Researcher at National Institutes of Health
Publications - 13
Citations - 207
Kirsten C. Verhein is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Genome-wide association study & Inflammation. The author has an hindex of 8, co-authored 13 publications receiving 176 citations. Previous affiliations of Kirsten C. Verhein include Oregon Health & Science University.
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Journal ArticleDOI
Neural control of airway inflammation.
TL;DR: Cross-talk between airway nerves and leukocytes helps to maintain chronic inflammation and accentuates neural control of the airways.
Journal ArticleDOI
IL-1 receptors mediate persistent, but not acute, airway hyperreactivity to ozone in guinea pigs.
TL;DR: It is demonstrated that IL-1 mediates ozone-induced airwayhyperreactivity at 3 days, but not 1 day, after ozone exposure, and preventing hyperreactivity was accompanied by decreased eosinophil major basic protein deposition within the lung, suggesting that IL -1 affects eos inophil activation 3 days after ozone Exposure.
Journal ArticleDOI
Determinants of host susceptibility to murine respiratory syncytial virus (RSV) disease identify a role for the innate immunity scavenger receptor MARCO gene in human infants
Monica High,Hye Youn Cho,Jacqui Marzec,Tim Wiltshire,Kirsten C. Verhein,Mauricio T. Caballero,Patricio L. Acosta,Jonathan Ciencewicki,Zackary R. McCaw,Lester Kobzik,Laura Miller-DeGraff,Wes Gladwell,David B. Peden,M. Elina Serra,Min Shi,Clarice R. Weinberg,Oscar Suzuki,Xuting Wang,Douglas A. Bell,Fernando P. Polack,Steven R. Kleeberger +20 more
TL;DR: A human MARCO promoter SNP was characterized that caused loss of gene expression, increased in vitro cellular response to RSV infection, and associated with increased risk of disease severity in two independent populations of children infected with RSV.
Journal ArticleDOI
Genome-wide association mapping of acute lung injury in neonatal inbred mice
Jennifer L. Nichols,Wesley Gladwell,Kirsten C. Verhein,Hye Youn Cho,Jürgen Wess,Oscar Suzuki,Tim Wiltshire,Steven R. Kleeberger +7 more
TL;DR: This study evaluated the role of genetic background in response to oxidant stress in the neonatal lung by exposing mice from 36 inbred strains toHyperoxia (95% O2) for 72 h after birth and found hyperoxia‐induced lung injury was significantly reduced in neonatal mice with targeted deletion of Chrm2, relative to wild‐type controls.
Journal ArticleDOI
Novel Roles for Notch3 and Notch4 Receptors in Gene Expression and Susceptibility to Ozone-Induced Lung Inflammation in Mice.
Kirsten C. Verhein,Zachary R. McCaw,Wesley Gladwell,Shweta Trivedi,Pierre R. Bushel,Steven R. Kleeberger +5 more
TL;DR: Novel roles for Notch3 and Notch4 receptors in gene expression and susceptibility to ozone-induced lung inflammation in mice are suggested, and suggest that Notch receptors protect against innate immune inflammation.