J
Jacqui Marzec
Researcher at National Institutes of Health
Publications - 21
Citations - 941
Jacqui Marzec is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Single-nucleotide polymorphism & Virus. The author has an hindex of 11, co-authored 19 publications receiving 749 citations.
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Journal ArticleDOI
Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury
Jacqui Marzec,Jason D. Christie,Sekhar P. Reddy,Anne E. Jedlicka,Hue Vuong,Paul N. Lanken,Richard Aplenc,Tae Yamamoto,Masayuki Yamamoto,Hye Youn Cho,Steven R. Kleeberger +10 more
TL;DR: This translational investigation provides novel insight into the molecular mechanisms of susceptibility to ALI and may help to identify patients who are predisposed to develop ALI under at risk conditions, such as trauma and sepsis.
Journal ArticleDOI
Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response
Krist Helen Antunes,José Luís Fachi,Rosemeire O. F. de Paula,Emanuelle Fraga da Silva,Laís Passariello Pral,Adara Aurea dos Santos,Greicy Dias,José Eduardo Vargas,Renato David Puga,Fabiana Quoos Mayer,Fábio Luiz Dal Moro Maito,Carlos R. Zárate-Bladés,Nadim J. Ajami,Marcella Ramos Sant'Ana,Thamiris Candreva,Hosana G. Rodrigues,Marcio Schmiele,Maria Teresa Pedrosa Silva Clerici,José Luiz Proença-Módena,Angélica Thomas Vieira,Charles R. Mackay,Daniel S. Mansur,Mauricio T. Caballero,Jacqui Marzec,Jianying Li,Xuting Wang,Douglas A. Bell,Fernando P. Polack,Steven R. Kleeberger,Renato T. Stein,Marco Aurélio Ramirez Vinolo,Ana Paula de Souza +31 more
TL;DR: It is reported that microbiota-derived acetate protects mice against RSV infection via GPR43- mediated type 1 interferon response induction in the lungs and engagement of Gpr43 and IFNAR.
Journal ArticleDOI
TLR4 genotype and environmental LPS mediate RSV bronchiolitis through Th2 polarization
Mauricio T. Caballero,M. Elina Serra,Patricio L. Acosta,Jacqui Marzec,Luz Gibbons,Maximiliano Salim,Andrea Rodriguez,Andrea Reynaldi,Alejandro Garcia,Daniela Bado,Ursula J. Buchholz,Diego R. Hijano,Silvina Coviello,Dawn C. Newcomb,Miguel Bellabarba,Fausto M Ferolla,Romina Libster,Ada Berenstein,Susana Siniawaski,Valeria Blumetti,Marcela Echavarria,Leonardo Araújo Pinto,Andrea Lawrence,M. Fabiana Ossorio,Arnoldo Grosman,Cecilia Gabriela Mateu,Carola Bayle,Alejandra Dericco,Mariana Pellegrini,Ignacio Igarza,Horacio A. Repetto,Luciano Alva Grimaldi,Prathyusha Gudapati,Norberto R. Polack,Fernando Althabe,Min Shi,Fernando Ferrero,Eduardo Bergel,Renato T. Stein,R. Stokes Peebles,Mark Boothby,Steven R. Kleeberger,Fernando P. Polack +42 more
TL;DR: Environmental and genetic factors that influence RSV pathogenesis are identified and reveal that a high IL-4/IFN-γ ratio is associated with severe disease and these molecules should be explored as potential targets for therapeutic intervention.
Journal ArticleDOI
Functional polymorphisms in Nrf2: implications for human disease
TL;DR: An overview of the human Nrf2 gene and protein domain is presented, identification of genetic mutations in NRF2 and associations of the mutations with multiple diseases, and the role of somatic mutations inNrf2 in diseases, primarily various cancers are presented.
Journal ArticleDOI
Polymorphisms in the transcription factor NRF2 and forearm vasodilator responses in humans.
Ewa D. Marczak,Jacqui Marzec,Darryl C. Zeldin,Steven R. Kleeberger,Nancy J. Brown,Mias Pretorius,Craig R. Lee +6 more
TL;DR: Polymorphisms within the NFE2L2 promoter were associated with impaired forearm vasodilator responses in an endothelial-independent manner, suggesting an important role of NRF2 in the regulation of vascular function in humans.