K
Kirsten Falk
Researcher at Max Delbrück Center for Molecular Medicine
Publications - 94
Citations - 10957
Kirsten Falk is an academic researcher from Max Delbrück Center for Molecular Medicine. The author has contributed to research in topics: Major histocompatibility complex & MHC class I. The author has an hindex of 42, co-authored 94 publications receiving 10665 citations. Previous affiliations of Kirsten Falk include Harvard University & Singapore Immunology Network.
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Journal ArticleDOI
Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules.
TL;DR: Each MHC class I allele has its individual rules to which peptides presented in the groove adhere, and this information about the contents of MHC grooves is now provided.
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Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression
Giovanna Borsellino,Markus Kleinewietfeld,Diletta Di Mitri,Alexander Sternjak,Adamo Diamantini,Raffaella Giometto,Sabine Höpner,Diego Centonze,Giorgio Bernardi,Maria Luisa Dell'Acqua,Paolo Maria Rossini,Luca Battistini,Olaf Rötzschke,Kirsten Falk +13 more
TL;DR: In humans CD39 is a marker of a Treg subset likely involved in the control of the inflammatory autoimmune disease and Notably, patients with the remitting/relapsing form of multiple sclerosis have strikingly reduced numbers of CD39(+) Treg cells in the blood.
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Peptides Naturally Presented by MHC Class I Molecules
TL;DR: The peptide specificity of class I molecules and experimental evidence indicate that T cells are tolerant to only a small fraction of the expressed genomic sequences and are not tolerant to the remainder.
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Isolation and analysis of naturally processed viral peptides as recognized by cytotoxic T cells.
Olaf Rötzschke,Kirsten Falk,Karl Deres,Hansjörg Schild,Maria Norda,Jörg W. Metzger,Günther Jung,Hans-Georg Rammensee +7 more
TL;DR: It is shown that naturally processed viral peptides can be extracted from virus-infected cells by acid elution, both smaller than the corresponding synthetic peptides, which have first been used to determine the respective CTL epitopes.
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Cellular peptide composition governed by major histocompatibility complex class I molecules
TL;DR: It is shown that the MHC molecules themselves are substantially involved in determining which peptides occur intracellularly: normal mouse spleen cells identical at all genes but MHC class I express different patterns of peptides derived from cellular non-MHC proteins.