K
Kirsten L. Viola
Researcher at Northwestern University
Publications - 43
Citations - 11812
Kirsten L. Viola is an academic researcher from Northwestern University. The author has contributed to research in topics: Alzheimer's disease & Amyloid beta. The author has an hindex of 22, co-authored 36 publications receiving 10846 citations. Previous affiliations of Kirsten L. Viola include Merck & Co..
Papers
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Journal ArticleDOI
Intranasal passive immunization using WGA-modified oligomer antibodies greatly improves learning and memory in Alzheimer's 5XFAD mice
Neelima B. Chauhan,Chun Xiao,Francesca Davis,Mary P. Lambert,Kirsten L. Viola,Pascale N. Lacor,Vinayak P. Dravid,William L. Klein +7 more
TL;DR: It is suggested that propofol dampened the neuroinflammatory effects of surgery and implies that anesthetic management might modulate the long term outcome after surgery in elderly patients with risk factors for Alzheimer’s disease.
Patent
Method for detecting soluble oligomeric amyloid beta
TL;DR: A method for detecting soluble oligomeric amyloid β in a subject using, e.g., PET is provided in this paper, where the PET is used to detect the presence of amyloids.
Journal ArticleDOI
Diet‐induced Alzheimer's‐like syndrome in the rabbit
Craig Weiss,Nicola Bertolino,Daniel Procissi,Grazia Aleppo,Quinn C. Smith,Kirsten L. Viola,Samuel C. Bartley,William L. Klein,John F. Disterhoft +8 more
TL;DR: It is proposed that mechanisms underlying LOAD can be assessed by stressing risk factors for inducing AD and that dietary manipulations can be used to assess etiological differences in the pathologies and effectiveness of potential therapeutics against LOAD.
Posted ContentDOI
Amyloid β oligomer selective antibodies for Alzheimer’s therapeutics and diagnostics
Kirsten L. Viola,Maira A. Bicca,Adrian M. Bebenek,Daniel L. Kranz,Vikas Nandwana,Emily A. Waters,Chad R. Haney,Maxwell Lee,Abhay Gupta,Zach Brahmbhatt,Weijian Huang,Ting-Tung Chang,Anderson Peck,Clarissa Valdez,Vinayak P. Dravid,William L. Klein +15 more
TL;DR: In this paper, a promising anti-A{beta}O diagnostic probe was introduced, which was able to distinguish the 5xFAD mouse model from wild type mice by PET and MRI.
Posted ContentDOI
The therapeutic and diagnostic potential of amyloid β oligomers (AβOs) selective antibodies to treat Alzheimer’s disease
Kirsten L. Viola,Maira A. Bicca,Adrian M. Bebenek,Daniel L. Kranz,Vikas Nandwana,Emily A. Waters,Chad R. Haney,Maxwell Lee,Abhay Gupta,Zach Brahmbhatt,Weijian Huang,Ting-Tung Chang,Anderson Peck,Clarissa Valdez,Vinayak P. Dravid,William L. Klein +15 more
TL;DR: In this paper, the role of endogenous AβOs in instigating memory loss and salient AD neuropathology was further supported by a promising anti-AβO diagnostic probe capable of distinguishing the 5xFAD mouse model from wild type mice by PET and MRI.