K
Kirsti McElwain
Researcher at University of California, San Diego
Publications - 10
Citations - 1003
Kirsti McElwain is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Fibrosis & Epithelium. The author has an hindex of 10, co-authored 10 publications receiving 979 citations.
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Journal ArticleDOI
Inhibition of airway remodeling in IL-5-deficient mice.
Jae Youn Cho,Marina Miller,Kwang Je Baek,Ji Won Han,Jyothi Nayar,Sook Young Lee,Kirsti McElwain,Shauna McElwain,Stephanie Friedman,David H. Broide +9 more
TL;DR: An important role for IL-5, eosinophils, alphaVbeta6, and TGF-beta in airway remodeling is suggested, and increased airway epithelial expression of alphaV beta6 integrin may contribute to the increased activation of latent T GF-beta.
Journal ArticleDOI
Allergen-induced peribronchial fibrosis and mucus production mediated by IκB kinase β-dependent genes in airway epithelium
David H. Broide,Toby Lawrence,Taylor A. Doherty,Jae Youn Cho,Marina Miller,Kirsti McElwain,Shauna McElwain,Michael Karin +7 more
TL;DR: An important role for NF-κB regulated genes in airway epithelium in allergen-induced airway remodeling, including peribronchial fibrosis and mucus production is shown.
Journal ArticleDOI
Accumulation of Peribronchial Mast Cells in a Mouse Model of Ovalbumin Allergen Induced Chronic Airway Inflammation: Modulation by Immunostimulatory DNA Sequences
Reid K. Ikeda,Marina Miller,Jyothi Nayar,Linda L. Walker,Jae Youn Cho,Kirsti McElwain,Shauna McElwain,Eyal Raz,David H. Broide +8 more
TL;DR: It is demonstrated that OVA-sensitized mice exposed to repetitive OVA inhalation for 1–6 mo have an accumulation of peribronchial mast cells and express increased levels of mast cell growth factors in the lung.
Journal ArticleDOI
Reduced peribronchial fibrosis in allergen-challenged MMP-9-deficient mice
TL;DR: It is demonstrated that MMP-9 may play a role in mediating selected aspects of allergen-induced airway remodeling but does not play a significant role in mucus expression, smooth muscle thickness, or airway responsiveness.
Journal ArticleDOI
Immunostimulatory DNA Inhibits Transforming Growth Factor-β Expression and Airway Remodeling
Jae Youn Cho,Marina Miller,Kwang Je Baek,Ji Won Han,Jyothi Nayar,Monica Rodriguez,Sook Young Lee,Kirsti McElwain,Shauna McElwain,Eyal Raz,David H. Broide +10 more
TL;DR: It is demonstrated that ISS prevents not only Th2-mediated airway inflammation in response to acute allergen challenge, but also airway remodeling associated with chronic allergenic challenge.