Jae Youn Cho

TL;DR: An important role for IL-5, eosinophils, alphaVbeta6, and TGF-beta in airway remodeling is suggested, and increased airway epithelial expression of alphaV beta6 integrin may contribute to the increased activation of latent T GF-beta.

TL;DR: The data support the proposed negative feedback role for Siglec-F, represent the first in vivo demonstration of biologic functions for any CD33rSiglec, and predict a role for human SigLec-8 (the isofunctional paralog of mouse SigleC-F) in regulating the pathogenesis of human eosinophil-mediated disorders.

TL;DR: Evidence of the inducible nature of ORMDL3 ER expression in particular in bronchial epithelial cells is provided and an ER UPR pathway through which OR MDL3 may be linked to asthma is suggested.

TL;DR: The novel observation that adiponectin and functional AdipoR1 are expressed by lung epithelial cells is demonstrated, suggesting a potential autocrine and/or paracrine pathway for adip onectin to activate epithelial Cells in COPD-E.

TL;DR: Pharmacological inhibition of LIGHT using a fusion protein between the IgG Fc domain and lymphotoxin β receptor reduces lung fibrosis, smooth muscle hyperplasia and airway hyperresponsiveness in mouse models of chronic asthma, despite having little effect on airway eosinophilia.