Abstract Magnetic nanoparticles of Fe 3 O 4 encapsulated with Poly(D,L lactide-co-glycolide) (PLGA) were prepared for magnetic resonance imaging (MRI) contrast agent by using an emulsification–diffusion method. In this study, we have investigated the effects of homogenizer and agitator speed on the nanoparticles formation and the magnetic properties of ferrofluid nanoparticles encapsulated with PLGA with varying the ferromagnetic particle size from 10 to 180 nm. We have confirmed that the ferrofluid nanoparticles encapsulated with PLGA could be utilized as an MRI contrast agent from experiments in animal tissue.

Nanoparticles of Magnetic Ferric Oxides Encapsulated with Poly(D,L Laticde-Co Glycolide) and Their Applications to Magnetic Resonance Imaging Contrast Agent.

In vitro and in vivo evaluation of anti-nucleolin-targeted magnetic PLGA nanoparticles loaded with doxorubicin as a theranostic agent for enhanced targeted cancer imaging and therapy

With the increasing demand for wound care and treatment worldwide, traditional dressings have been unable to meet the needs of the existing market due to their limited antibacterial properties and other defects. Electrospinning technology has attracted more and more researchers’ attention as a simple and versatile manufacturing method. The electrospun nanofiber membrane has a unique structure and biological function similar to the extracellular matrix (ECM), and is considered an advanced wound dressing. They have significant potential in encapsulating and delivering active substances that promote wound healing. This article first discusses the common types of wound dressing, and then summarizes the development of electrospun fiber preparation technology. Finally, the polymers and common biologically active substances used in electrospinning wound dressings are summarized, and portable electrospinning equipment is also discussed. Additionally, future research needs are put forward.

Electrospun Medicated Nanofibers for Wound Healing: Review

Recent advances in PVA-polysaccharide based hydrogels and electrospun nanofibers in biomedical applications: A review.

In this work, we report the synthesis and characterization of a new hybrid nanoparticles system performed by magnetite nanoparticles, loaded in a PLGA matrix, and stabilized by different concentrations of chitosan. Magnetite nanoparticles were hydrophobized with oleic acid and entrapped in a PLGA matrix by the emulsion solvent evaporation method, after that, magnetite/PLGA/chitosan nanoparticles were obtained by adding dropwise magnetite/PLGA nanoparticles in chitosan solutions. Magnetite/PLGA nanoparticles produced with different molar ratios did not show significant differences in size and the 3:1 molar ratio showed best spherical shapes as well as uniform particle size. Isothermal titration calorimetry studies demonstrated that the first stage of PLGAchitosan interaction is mostly regulated by electrostatic forces. Based on a single set of identical sites model, we obtained for the average number of binding sites a value of 3.4, which can be considered as the number of chitosan chains per nanoparticle. This value was confirmed by using a model based on theDLVO theory and fitting zeta potential measurements of magnetite/PLGA/chitosan nanoparticles. From the adjusted parameters, we found that an average number of chitosan molecules of 3.6 per nanoparticle are attached onto the surface of the PLGA matrix. Finally, we evaluated the effect of surface charge of nanoparticles on a membrane model of endothelial cells performed by a mixture of three phospholipids at the air-water interface. Different isotherms and adsorption curves show that cationic surface of charged nanoparticles strongly interact with the phospholipids mixture and these results can be the basis of future experiments to understand the nanoparticles-cell membrane interaction.

https://iopscience.iop.org/article/10.1088/2053-1591/2/9/095010/pdf

Synthesis and characterization of magnetite/PLGA/chitosan nanoparticles

Oleic acid-coated superparamagnetic iron oxide nanoparticles (Fe3O4) encapsulated within poly(d,l-lactide-co-glycolide) (PLGA) particles were prepared by the w/o/w emulsion technique using poly(vinyl alcohol) as a dispersant. The concentration of PLGA in the oil phase was varied (5, 15, 30, 45, and 60 mg/ml) at constant magnetite concentration in the oil phase (5 mg/ml) to study the properties of composite Fe3O4–PLGA nanoparticles. Even though PLGA concentration varied widely in the oil phase, the weight percent of 7–16 nm diameter magnetite in the particles varied only from 56 to 62 % (23–28 vol.%). The obtained composite nanoparticles were essentially spherical with magnetite spatially uniformly dispersed in individual PLGA particles, as measured by transmission electron microscopy (TEM). Also, the magnetite concentration in each particle did not vary widely as determined qualitatively via microscopy. Hydrodynamic diameters of the composite nanoparticles as measured by dynamic light scattering increased by approximately 10 % with added magnetite, with a smaller relative increase in diameter measured by TEM. The zeta potential of the particles was about −26 mV, independent of Fe3O4 loading. Relatively high saturation magnetizations (36–45 emu/g) were measured for these highly loaded particles, with the latter value only 7 emu/g lower than the value measured for the oleic acid-coated particles alone.

Synthesis and encapsulation of magnetite nanoparticles in PLGA: effect of amount of PLGA on characteristics of encapsulated nanoparticles

In this paper, poly(d,l-lactide-co-glycolide) (PLGA) nanospheres loading with a protein drug were incorporated in poly(vinyl alcohol)/Aloe vera (PVA/AV) nanofibers by electrospinning as a novel wou...

Poly(d,l-lactide-co-glycolide) nanospheres within composite poly(vinyl alcohol)/aloe vera electrospun nanofiber as a novel wound dressing for controlled release of drug

Poly(D,L-lactide-co-glycolide) (PLGA) with encapsulated hydrophobic magnetite (Fe3O4) nanoparticles or hydroxyapatite (HAp) nanoparticles were prepared by the w/o/w emulsion technique. The weight ratios of nanoparticles (Fe3O4 or HAp) to PLGA and polymer molecular weight were varied in the oil phase and the properties of the composite nanoparticles were studied. The final weight percent of nanoparticles in the spherical PLGA particles varied from ~ 5 to 60 wt%. Hydrodynamic diameters of the composite nanoparticles as measured by dynamic light scattering (DLS) were found to decrease with decreasing polymer molecular weight and were independent of nanoparticle loading. Particle sizes measured from TEM were smaller by almost a factor of two vs. those obtained from DLS. The zeta potentials of the particles were about − 23 mV, independent of polymer molecular weight and nanoparticle loading within statistical significance. In vitro cytotoxicity tests show a high level of cytocompatibility suggesting satisfactory biocompatibility for biomedical applications.

Magnetite/poly(D,L-lactide-co-glycolide) and hydroxyapatite/poly(D,L-lactide-co-glycolide) prepared by w/o/w emulsion technique for drug carrier: physical characteristic of composite nanoparticles

Biocompatible polymeric carriers containing inorganic materials for delivering therapeutic agents to a targeted site are promising candidate for drug delivery. Two nanocomposite nanoparticl...

Magnetite/Poly(D,l-Lactide-co-Glycolide) and Hydroxyapatite/ Poly(D,l-Lactide-co-Glycolide) Prepared by W/O/W Emulsion Technique for Drug Carrier; Evaluation of In vitro Release of Dexamethasone From Composite Nanoparticles

Kittima Bootdee

Papers

Synthesis and encapsulation of magnetite nanoparticles in PLGA: effect of amount of PLGA on characteristics of encapsulated nanoparticles

Poly(d,l-lactide-co-glycolide) nanospheres within composite poly(vinyl alcohol)/aloe vera electrospun nanofiber as a novel wound dressing for controlled release of drug

Magnetite/poly(D,L-lactide-co-glycolide) and hydroxyapatite/poly(D,L-lactide-co-glycolide) prepared by w/o/w emulsion technique for drug carrier: physical characteristic of composite nanoparticles

Magnetite/Poly(D,l-Lactide-co-Glycolide) and Hydroxyapatite/ Poly(D,l-Lactide-co-Glycolide) Prepared by W/O/W Emulsion Technique for Drug Carrier; Evaluation of In vitro Release of Dexamethasone From Composite Nanoparticles