Showing papers in "International Journal of Polymeric Materials in 2018"
TL;DR: This review paper presents an overview of different preparation methods of polymeric and novel lipid-based (niosome and solid lipid) nanoparticles.
Abstract: A wide number of drug nanocarriers have emerged to improve medical therapies, and in particular to achieve controlled delivery of drugs, genes or gene expression-modifying compounds, or vaccine antigens to a specific target site. Of the nanocarriers, lipid-based and polymeric nanoparticles are the most widely used. Lipid-based systems like niosomes and liposomes are non-toxic self-assembly vesicles with an unilamellar or multilamellar structure, which can encapsulate hydrophobic/hydrophilic therapeutic agents. Polymeric nanoparticles, usually applied as micelles, are colloidal carriers composed of biodegradable polymers. Characteristics such as loading capacity, drug release rate, physical and chemical stability, and vesicle size are highly dependent on experimental conditions, and material and method choices at the time of preparation. To be able to develop effective methods for large scale production and to meet the regulatory requirements for eventual clinical implementation of nanocarriers, on...
132 citations
TL;DR: In this article, a water-insoluble bioactive compounds typically require the formulation of lipophilic, antimicrobial delivery system to enhance their bio accessibility, and a healthy delivery system, in this contrast, play an important role.
Abstract: Water-insoluble bioactive compounds typically require the formulation of lipophilic, antimicrobial delivery system to enhance their bio accessibility. Edible delivery system, in this contrast, play...
49 citations
TL;DR: The cytotoxicity results revealed that the TMZ-loaded PCL-Diol-b-PU core–shell nanofibers could be used as a drug delivery implant to deliver TMZ against glioblastoma tumors.
Abstract: The electrospun biocompatible poly (e-caprolactonediol)-based polyurethane (PCL-Diol-b-PU) core/shell nanofibrous scaffolds were prepared via the coaxial electrospinning process. Temozolomi...
34 citations
TL;DR: Lipid polymer hybrid nanoparticles enable the researchers to formulate a carrier system that will be able to provide targeted anticancer drug delivery, and special focus has been given to the colorectal cancer.
Abstract: Cancer has been the most deleterious disease since few decades and its prevalence is increasing day by day. Scientists have developed many novel carrier systems to modify the delivery of anticancer...
33 citations
TL;DR: In vitro cytotoxicity of scaffolds toward human mesenchymal stem cell line was evaluated through the evaluation of cell viability and cell attachment assays.
Abstract: In this study, chitosan-based novel scaffolds containing zeolite A were fabricated by freeze-drying technique. The nanocomposite scaffolds were prepared from chitosan and zeolite A nanocrystals wit...
27 citations
TL;DR: Designing the novel conductive and biodegradable scaffolds based on star-like hyperbranched terpolymers of aliphatic polyester–poly(D,L-lactide)–polyaniline (S-HAP–PLA–PANI) was the purpose of this research.
Abstract: Designing the novel conductive and biodegradable scaffolds based on star-like hyperbranched terpolymers of aliphatic polyester–poly(D,L-lactide)–polyaniline (S-HAP–PLA–PANI) was the purpose...
26 citations
TL;DR: The SEM results of cultured RPE on gelatin/chitosan scaffolds showed the appropriate adhesion of cells on the substrate, and indicated that a large number of cells strongly expressed RPE65 and cytokeratin 8/18 were cultured on the scaffolds.
Abstract: Damage of the retinal pigmented epithelial cells causes various diseases such as age-related macular degeneration in retinal tissue. Nowadays, scientists are attempting to replace lost retinal cell...
25 citations
TL;DR: It was believed that PCL/gelatin scaffolds could be used as substrates to replace RPE extracellular matrix to facilitate regeneration of RPE layer in retinal diseases.
Abstract: Different ratios of poly(e-caprolactone) (PCL) and gelatinwere used to fabricate scaffolds for regeneration of retinal pigment epithelium (RPE) layer. Physical and chemical characterizations were p...
25 citations
TL;DR: In this article, functionalized multiwall carbon nanotubes (f-MWCNTs) were used to reinforce the freeze-dried gelatin (G)/chitosan (Ch) scaffolds for bone graft substitution.
Abstract: Functionalized multiwall carbon nanotubes (f-MWCNTs) were used to reinforce the freeze-dried gelatin (G)/chitosan (Ch) scaffolds for bone graft substitution. Two types of G/Ch scaffolds at a ratio of 2:1 and 3:1 by weight incorporated with 0.025, 0.05, or 0.1 and 0.2 or 0.4 wt% f-MWCNT, respectively, were prepared by freeze drying, and their structure, morphology, and physicochemical and compressive mechanical properties were evaluated. The scaffolds exhibited porous structure with pore size of 80–300 and 120–140 µm for the reinforced scaffolds of G/Ch 2:1 and 3:1, respectively, and porosity 90–93% which slightly decreased with an increase in f-MWCNTs content for both types. Incorporation of f-MWCNTs led to 11- and 9.6-fold increase in modulus, with respect to their pure biopolymer blend scaffolds at a level of 0.05 wt% for G/Ch 2:1 and 0.2 wt% for G/Ch 3:1, respectively. The higher content of f-MWCNTs resulted in loss of mechanical properties due to agglomeration. The highest value of compressive...
24 citations
TL;DR: A pH-responsive polymer derived from polyethyleneimine with zwitterionic function was used as a shell around super paramagnetic iron oxide nanoparticles (SPIONs) to introduce an efficient drug car as discussed by the authors.
Abstract: A pH-responsive polymer derived from polyethyleneimine with zwitterionic function was used as a shell around super paramagnetic iron oxide nanoparticles (SPIONs), to introduce an efficient drug car...
24 citations
TL;DR: It is concluded that the aligned nanofibrous scaffold with higher PLGA ratio could significantly enhance hBMMSC proliferation and differentiation to chondrocytes.
Abstract: The simultaneous effect of electrospun scaffold alignment and polymer composition on chondrogenic differentiation of human bone marrow mesenchymal stem cells (hBMMSC) is investigated. Aligned and r...
TL;DR: In this article, Salicylic acid (SA)/polyurethane (PU) composite nanofiber mats were fabricated by introducing SA in PU solution during the electrospinning process.
Abstract: Salicylic acid (SA)/polyurethane (PU) composite nanofiber mats were fabricated by introducing SA in PU solution during the electrospinning process. Cell viability assays showed that the as-prepared...
TL;DR: An advanced surface imprinting technique, i.e., the technique of synchronously graft/crosslinking polymerizing of monomer and imprinting of template on the surface of membrane, was designed and use as discussed by the authors.
Abstract: An advanced surface imprinting technique, i.e., the technique of synchronously graft/crosslinking polymerizing of monomer and imprinting of template on the surface of membrane, was designed and use...
TL;DR: Chitosan-Silver nanocomposites (CS-HDA-AgNCs) as discussed by the authors were used to make a flexible and flexible film, which can be applied to a wide range of applications.
Abstract: Chitosan–silver nanocomposites (CS-HDA-AgNCs) was prepared using chitosan, biogenic silver nanocomposites, and crosslinker, hexamethylene 1,6-di(amino carboxysulfonate) (HDA). The film is flexible ...
TL;DR: The focus of most investigations is on designing the most efficient PLGA formulation and improving its effectiveness with various synthesis and postsynthesis modifications.
Abstract: Among all polymers, without doubt, poly(lactic-co-glycolic acid) (PLGA) is the most popular one in biology and biomedicine fields. Having a tunable structure, a controllable and desired release pro...
TL;DR: In this article, a series of microwave irradiated IPN of Crg and GG have been synthesized and cross linking through hydrogen bonding was confirmed by FTIR spectroscopy.
Abstract: A series of microwave irradiated IPN of Crg and GG have been synthesized and cross linking through hydrogen bonding was confirmed by FTIR spectroscopy. Thermal sensitivity at 48°C, degradation abov...
TL;DR: In this paper, a biomimetic vascular graft scaffolds were produced by electrospinning method with the most superior characteristics to be a proper biomimetically small diameter blood vessel using Polycaprolactone(PCL), Ethyl Cellulose(EC) and Collagen Type-1.
Abstract: A novel biomimetic vascular graft scaffolds were produced by electrospinning method with the most superior characteristics to be a proper biomimetic small diameter blood vessel using Polycaprolactone(PCL), Ethyl Cellulose(EC) and Collagen Type-1 were used to create the most convenient synergy of a natural and synthetic polymer to achieve similarity to native small diameter blood vessels. Scanning Electron Microscopy(SEM), Fourier Transform Infrared Spectroscopy(FTIR), Differential Scanning Calorimetry Analysis(DSC), tensile measurement tests, and in-vitro and in-vivo applications were performed. Results indicated significant properties such as having 39.33 nm minimum, 104.98 nm average fiber diameter, 3.2 MPa young modulus and 135% relative cell viability.
TL;DR: In this paper, the authors synthesize biogenic polyhydroxyalkanoate (PHA) nanoparticles from Bacillus subtilis NCDC0671 using orange peel medium.
Abstract: The present research work was initiated to synthesize biogenic polyhydroxyalkanoate (PHA) nanoparticles from Bacillus subtilis NCDC0671 using orange peel medium. Sequential and systematic optimizat...
TL;DR: In this article, the physical and biological properties of the BC dressing were improved by incorporation of silk sericin (SS), polyhexamethylene biguanide (PHMB), and glycerin.
Abstract: Bacterial cellulose (BC) has been applied for wound dressing application. In this study, physical and biological properties of the BC dressing were improved by incorporation of silk sericin (SS), polyhexamethylene biguanide (PHMB), and glycerin. The glycerin incorporation reduced dehydration rate and wound adhesion of the BC dressing in a concentration-dependent manner. PHMB, an antiseptic agent, provided antibacterial activity against Gram-positive and Gram-negative bacteria. Meanwhile, SS would enhance collagen and tissue formation in wounds. Finally, we confirmed that the BC dressing incorporating SS, PHMB, and glycerin was safe to be used as a medical material according to ISO 10993-6 standard.
TL;DR: In this paper, the effect of plasma treatment on the release kinetics of the drug Temozolomide (TMZ) from thin, biodegradable polyester films, comprising polylactic acid (PLA) and poly...
Abstract: Investigation was made into the effect of plasma treatment on the release kinetics of the drug Temozolomide (TMZ) from thin, biodegradable polyester films, comprising polylactic acid (PLA) and poly...
TL;DR: Stimuli-responsive nanostructures were developed as anticancer drug delivery carriers in this paper, where poly(2-hydroxyethylmethacrylate)-b-(N-isopropylacrylamide) (poly(HEMA-b-NIPAAm)) diblock was used.
Abstract: Stimuli-responsive nanostructures were developed as anticancer drug delivery carriers. To this end, poly(2-hydroxyethylmethacrylate)-b-(N-isopropylacrylamide) (poly(HEMA-b-NIPAAm)) diblock ...
TL;DR: Applications of poly(N-isopropylacrylamide-vinyl acetic acid) microgels in the field of nanotechnology, drug loading and delivery vehicle, morphology-tuned applications, optical etalon formation and catalysts have been discussed in detail.
Abstract: Vinyl acetic acid comonomers-based microgels exhibit exceptional behavior and morphological properties as compared to other comonomer polymerized microgels. High hydrophobic character of vi...
TL;DR: Results suggest that collagen-based scaffolds offer excellent biocompatibility for bone regeneration, where thisBiocompatible nature of scaffold leads to the proliferation of cells that lead to the deposition of mineral on the scaffold.
Abstract: Bone tissue engineering using in situ forming 3D scaffolds can be an alternative to surgically treated scaffolds. This work aimed to develop in situ forming scaffolds using poly (lactic-co-glycolic...
TL;DR: In this paper, the synthesis of montmorillonite (MMT)/poly(o-toluidine) (PoTD) nanocomposites prepared by confining PoTD in the galleries of MMT was reported.
Abstract: The present preliminary study reports the synthesis of montmorillonite (MMT)/poly(o-toluidine) (PoTD) nanocomposites prepared by confining PoTD in the galleries of MMT. X-ray diffraction confirmed the intercalation of PoTD at 25°C, while exfoliation was observed at higher loading. UV–visible spectroscopy showed the variation of polaronic transitions in the polymer. Scanning electron microscopy revealed the formation of a coarse granular structure. Rifampicin was chosen as a model drug to study the in vitro drug release characteristics of these nanocomposites. The nanocomposites revealed a sustained release behavior which could be utilized to design controlled release of antituberculosis drug carriers.
TL;DR: In this article, modification of poly(L-lactic acid) (PLLA) electrospun nanofibrous scaffolds blending with polyethylenimine (PEI) in different blend ratios was performed.
Abstract: In this study, modification of poly(L-lactic acid) (PLLA) electrospun nanofibrous scaffolds blending with polyethylenimine (PEI) in different blend ratios was performed. The sample with 85:15 blend...
TL;DR: This review article focuses on the biocompatible polyphosphazenes and their utilization as regeneration of tissues, skeleton, and bones with a particular focus on materials that contains only polyph phosphazenes, blends of polyPhosphazene, and composites made from polyph phosphate.
Abstract: The skeleton performs motley of functions. Defected bones and metameric loss of bone are often resulted due to innate abnormalities and accidental injuries. An assessment is made on the diversity o...
TL;DR: The results of in vitro and in vivo studies indicate that the 3D fibrous PLA-S can be a potential wound dressing for wound repair, particularly when seeded with BMSCs.
Abstract: Tissue engineering has emerged as an alternative treatment to traditional grafts for skin wound healing. Three-dimensional nanofibers have been used extensively for this purpose due to their excell...
TL;DR: In this paper, the polyacrylonitrile (PAN)-based electrospun fiber-loaded nano-approach was introduced for more effective control of psoriasis.
Abstract: The aim of the present work was to introduce the novel and convenient nanoapproach for more effective control of psoriasis. In this study, the polyacrylonitrile (PAN)-based electrospun fiber-loaded...
TL;DR: A phytogenic feed additive (PFA) formulation was prepared with bioactive molecules, such as curcuminoids, gingerol, and carvacrol, by encapsulating in nanofiber isolated from turmeric spent (turmeric nano-fiber, TNF) as mentioned in this paper.
Abstract: A phytogenic feed additive (PFA) formulation was prepared with bioactive molecules—curcuminoids, gingerol, and carvacrol by encapsulating in nanofiber isolated from turmeric spent (turmeric nanofiber, TNF). This formulation was completely characterized by scanning electron microscope, ultra performance liquid chromatography, and gas chromatography and evaluated for its efficacy. PFA-encapsulated TNF (PFA@TNF) considerably increased mean body weight, decreased cholesterol level, mortality rate, and reduced Escherichia coli content of broilers than antibiotic growth promoter (AGP). The depth of crypts in the ileum of broilers was considerably reduced by the inclusion of PFA@TNF in diets compared with the AGP.
TL;DR: In this comprehensive review, various reported polymeric nano-delivery systems for sorafenib are comprehensively covered.
Abstract: Sorafenib is the only approved targeted agent against hepatocellular carcinoma (HCC). It has several limitations predominantly poor aqueous solubility and hepatic first-pass effect that limits its oral delivery leading to low bioavailability, large inter-subject variability, narrow therapeutic window and side effects. Tosylate is used to improve its solubility, which is practically insoluble in water (60 µg/mL) so problems with sorafenib solubility persist. To improve the paharmacokinetic profile, minimize the side effects, and targeting drug to the tumor tissues, several polymeric nano-formulations are being evaluated. In this comprehensive review, various reported polymeric nano-delivery systems for sorafenib are comprehensively covered.