K
Kiyomi Nishimaki
Researcher at Kagoshima Women's Junior College
Publications - 4
Citations - 236
Kiyomi Nishimaki is an academic researcher from Kagoshima Women's Junior College. The author has contributed to research in topics: Mitochondrial DNA & Aldehyde dehydrogenase. The author has an hindex of 4, co-authored 4 publications receiving 221 citations.
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Age-Dependent Neurodegeneration Accompanying Memory Loss in Transgenic Mice Defective in Mitochondrial Aldehyde Dehydrogenase 2 Activity
TL;DR: Object recognition and Morris water maze tests revealed that the onset of cognitive impairment correlated with the degeneration, which was further accelerated by APOE (apolipoprotein E) knock-out; therefore, the accumulation of toxic aldehydes is by itself critical in the progression of neurodegenerative disease, which could be suppressed by ALDH2.
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Functional integrity of mitochondrial genomes in human platelets and autopsied brain tissues from elderly patients with Alzheimer's disease.
Sayaka Ito,Shigeo Ohta,Kiyomi Nishimaki,Yasuo Kagawa,Rika Soma,Shinya Kuno,Yasuko Komatsuzaki,Hidehiro Mizusawa,Jun-Ichi Hayashi +8 more
TL;DR: Functional integrity of mtDNA in both platelets and brain tissues of elderly patients with AD is suggested, warranting the reassessment of the conventional concept that the accumulation of pathogenic mutations in mtDNA throughout the aging process is responsible for the decrease of mitochondrial respiration capacity with age.
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Alzheimer's disease and DLST genotype
Journal ArticleDOI
Protective Effect of Hydrogen Gas Inhalation on Muscular Damage Using a Mouse Hindlimb Ischemia-Reperfusion Injury Model.
Mai Watanabe,Naomi Kamimura,Katsuya Iuchi,Kiyomi Nishimaki,Takashi Yokota,Rei Ogawa,Shigeo Ohta +6 more
TL;DR: The findings suggest that the optimal route for hydrogen delivery is continuous inhalation of hydrogen gas, which could be a novel clinical mode of treatment in ischemia-reperfusion injury.