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Shigeo Ohta

Researcher at Juntendo University

Publications -  279
Citations -  18698

Shigeo Ohta is an academic researcher from Juntendo University. The author has contributed to research in topics: Oxidative stress & Mitochondrion. The author has an hindex of 69, co-authored 272 publications receiving 17186 citations. Previous affiliations of Shigeo Ohta include University of Tokyo & University of Tsukuba.

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Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals

TL;DR: In this article, the authors showed that hydrogen (H2 )h can be used as an effective antioxidant therapy; owing to its ability to rapidly diffuse across membranes, it can reach and react with cytotoxic reactive oxygen species (ROS) and thus protect against oxidative damage.
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Deficiencies in Complex I subunits of the respiratory chain in Parkinson's disease

TL;DR: No clear difference was noted in immunoblotting studies on subunits of Complexes III and IV between the control and Parkinson's disease, but defects in Complex I subunits seem to be one of the most important clues to elucidate pathogenesis of Parkinson's Disease.
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Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction.

TL;DR: It is suggested that large-scale deletion mutations of mtDNA alone are sufficient for the mitochondrial dysfunction characteristic of CPEO.
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Free anterolateral thigh flaps for reconstruction of head and neck defects.

TL;DR: The anterolateral thigh flap is a septoutaneous artery flap based on the septocutaneous or muscle perforators of the lateral circumflex femoral system that is suitable for reconstruction of defects in an oral floor with tongue and esophageal deficits, scalp defects with dural defects, and for large full thickness defects of the lip.