S
Shigeo Ohta
Researcher at Juntendo University
Publications - 279
Citations - 18698
Shigeo Ohta is an academic researcher from Juntendo University. The author has contributed to research in topics: Oxidative stress & Mitochondrion. The author has an hindex of 69, co-authored 272 publications receiving 17186 citations. Previous affiliations of Shigeo Ohta include University of Tokyo & University of Tsukuba.
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Journal ArticleDOI
Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals
Ikuroh Ohsawa,Masahiro Ishikawa,Kumiko Takahashi,Megumi Watanabe,Kiyomi Nishimaki,Kumi Yamagata,Ken-ichiro Katsura,Yasuo Katayama,Sadamitsu Asoh,Shigeo Ohta +9 more
TL;DR: In this article, the authors showed that hydrogen (H2 )h can be used as an effective antioxidant therapy; owing to its ability to rapidly diffuse across membranes, it can reach and react with cytotoxic reactive oxygen species (ROS) and thus protect against oxidative damage.
Journal ArticleDOI
Deficiencies in Complex I subunits of the respiratory chain in Parkinson's disease
Yoshikuni Mizuno,Shigeo Ohta,Masashi Tanaka,Shinzaburo Takamiya,Keiji Suzuki,Takeshi Sato,Hiroshi Oya,Takayuki Ozawa,Yasuo Kagawa +8 more
TL;DR: No clear difference was noted in immunoblotting studies on subunits of Complexes III and IV between the control and Parkinson's disease, but defects in Complex I subunits seem to be one of the most important clues to elucidate pathogenesis of Parkinson's Disease.
Journal ArticleDOI
Introduction of disease-related mitochondrial DNA deletions into HeLa cells lacking mitochondrial DNA results in mitochondrial dysfunction.
TL;DR: It is suggested that large-scale deletion mutations of mtDNA alone are sufficient for the mitochondrial dysfunction characteristic of CPEO.
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Mitochondrial Genome Variation in Eastern Asia and the Peopling of Japan
Masashi Tanaka,Vicente M. Cabrera,Ana M. González,José M. Larruga,Takeshi Takeyasu,Takeshi Takeyasu,Noriyuki Fuku,Li Jun Guo,Li Jun Guo,Raita Hirose,Yasunori Fujita,Miyuki Kurata,Ken-ichi Shinoda,Kazuo Umetsu,Yoshiji Yamada,Yoshiji Yamada,Yoshiharu Oshida,Yuzo Sato,Nobutaka Hattori,Yoshikuni Mizuno,Yasumichi Arai,Nobuyoshi Hirose,Shigeo Ohta,Osamu Ogawa,Yasushi Tanaka,Ryuzo Kawamori,Masayo Shamoto-Nagai,Wakako Maruyama,Hiroshi Shimokata,Ryota Suzuki,Hidetoshi Shimodaira +30 more
TL;DR: Population-based comparisons confirmed that present-day Japanese have their closest genetic affinity to northern Asian populations, especially to Koreans, which finding is congruent with the proposed Continental gene flow to Japan after the Yayoi period.
Journal ArticleDOI
Free anterolateral thigh flaps for reconstruction of head and neck defects.
TL;DR: The anterolateral thigh flap is a septoutaneous artery flap based on the septocutaneous or muscle perforators of the lateral circumflex femoral system that is suitable for reconstruction of defects in an oral floor with tongue and esophageal deficits, scalp defects with dural defects, and for large full thickness defects of the lip.