Synthetic routes to tetrahydrofuran, tetrahydropyran, and spiroketal units of polyether antibiotics and a survey of spiroketals of other natural products

Macrolactonizations in the Total Synthesis of Natural Products

Nonanomeric spiroketals in natural products: structures, sources, and synthetic strategies.

Strategy and methodology development for the total synthesis of polyether ionophore antibiotics.

Financial support of the Spanish Ministry of Science and
Innovation (CTQ2012-38543-C03) and Generalitat Valenciana
(PROMETEO/2012/020) is acknowledged. V.M.-C. thanks the
Spanish Ministry of Science and Education for a predoctoral
fellowship (FPU AP2007-02562) and Generalitat Valenciana for
a VALi+d postdoctoral fellowship (APOSTD/2013/041).
M.D.P. thanks the Spanish Ministry of Education for a
postdoctoral fellowship and UGC India for a Startup Grant.

Macrocyclization Reactions: The Importance of Conformational, Configurational, and Template-Induced Preorganization

La synthese du dihydro erythronolide A s'effectue a partir du glucose via un traitement avec la dimethylamino-4 pyridine

Chiral synthesis of polyketide-derived natural products. 27. Stereoselective synthesis of erythronolide A via an extremely efficient macrolactonization by the modified Yamaguchi method

The formal total synthesis of the marine metabolite (+)-calyculin A is reported. The key steps involve (i) the use of Brown allylboration chemistry to control the relative and absolute stereochemis...

Applications of crotyldiisopinocampheylboranes in synthesis: a formal total synthesis of (+)-calyculin A

An enantioselective and geometrically selective synthesis of the C(1)–C(14) tetraene nitrile unit of calyculin A, using aldol chemistry with (+)-(E)-diisopinocampheylborane and Stille coupling, is described.

Stereocontrolled synthesis of calyculin A: construction of the C(1)–C(14) tetraene nitrile unit

In order to confirm the structures of some key intermediates employed in the total synthesis of salinomycin (1), natural 1 was cleaved into C1-C9, C10-C30, C10-C17, C21-C30, and C19-C30 segments.

Highly Stereocontrolled Total Synthesis of the Polyether Antibiotic Salinomycin. IV. Chemical Degradation of Salinomycin for the Structure Confirmation of Synthesic Key Intermediates

Synthetic studies of halichondrin b, an antitumor polyether macrolide isolated from a marine sponge 5. a highly concise and efficient synthesis of the c37-c54 tricyclic jkl-ring part

Kiyoshi Horita

Papers

Chiral synthesis of polyketide-derived natural products. 27. Stereoselective synthesis of erythronolide A via an extremely efficient macrolactonization by the modified Yamaguchi method

Applications of crotyldiisopinocampheylboranes in synthesis: a formal total synthesis of (+)-calyculin A

Stereocontrolled synthesis of calyculin A: construction of the C(1)–C(14) tetraene nitrile unit

Highly Stereocontrolled Total Synthesis of the Polyether Antibiotic Salinomycin. IV. Chemical Degradation of Salinomycin for the Structure Confirmation of Synthesic Key Intermediates

Synthetic studies of halichondrin b, an antitumor polyether macrolide isolated from a marine sponge 5. a highly concise and efficient synthesis of the c37-c54 tricyclic jkl-ring part