Klaus Hofmann-Kiefer

TL;DR: Undifferentiated fluid handling may increase the shift toward the interstitial space, because the endothelial glycocalyx plays a key role and is destroyed not only by ischemia and surgery, but also by acute hypervolemia.

TL;DR: Increased levels of CSF p-tau(231) may be a useful, clinically applicable biological marker for the differential diagnosis of AD, particularly for distinguishing AD from FTD.

TL;DR: Whether hydrocortisone and antithrombin stabilize the glycocalyx and, therefore, the vascular barrier, against damage induced by the inflammatory stimulus TNF-α is shown, thus improving the cardio-vascular situation and mitigating inflammation and tissue hypoxia.

TL;DR: Data indicate that an increased p-tau231 level is a potential risk factor for cognitive decline in patients with MCI, and independent, old age and APOE-&egr;4 carrier status were predictive as well.

TL;DR: Hydrocortisone preserves the endothelial glycocalyx, sustaining the vascular barrier and reducing interstitial edema, and the effect of colloids suggests that prevention of postischemic rise in coronary resistance by hydroc Cortisone could also be based on alleviation of endothelial swelling.