M
Markus Rehm
Researcher at Ludwig Maximilian University of Munich
Publications - 191
Citations - 8056
Markus Rehm is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Glycocalyx & Hydroxyethyl starch. The author has an hindex of 43, co-authored 187 publications receiving 7387 citations. Previous affiliations of Markus Rehm include University of Education, Winneba.
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Journal ArticleDOI
A rational approach to perioperative fluid management.
TL;DR: Undifferentiated fluid handling may increase the shift toward the interstitial space, because the endothelial glycocalyx plays a key role and is destroyed not only by ischemia and surgery, but also by acute hypervolemia.
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Rapid saline infusion produces hyperchloremic acidosis in patients undergoing gynecologic surgery
TL;DR: Infusion of 0.9% saline, but not lactated Ringer's solution, caused a metabolic acidosis with hyperchloremia and a concomitant decrease in the strong ion difference and the amount of weak plasma acid.
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Shedding of the Endothelial Glycocalyx in Patients Undergoing Major Vascular Surgery With Global and Regional Ischemia
Markus Rehm,Dirk Bruegger,Frank Christ,Peter Conzen,Manfred Thiel,Matthias Jacob,Daniel Chappell,Mechthild Stoeckelhuber,Ulrich Welsch,Bruno Reichart,Klaus Peter,Bernhard F. Becker +11 more
TL;DR: This study provides the first evidence in humans for shedding of the endothelial glycocalyx during ischemia/reperfusion procedures and shows that this structure plays a key role in the regulation of inflammation and vascular permeability.
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TNF-α induced shedding of the endothelial glycocalyx is prevented by hydrocortisone and antithrombin
Daniel Chappell,Klaus Hofmann-Kiefer,Matthias Jacob,Markus Rehm,Josef Briegel,Ulrich Welsch,Peter Conzen,Bernhard F. Becker +7 more
TL;DR: Whether hydrocortisone and antithrombin stabilize the glycocalyx and, therefore, the vascular barrier, against damage induced by the inflammatory stimulus TNF-α is shown, thus improving the cardio-vascular situation and mitigating inflammation and tissue hypoxia.
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Hypervolemia increases release of atrial natriuretic peptide and shedding of the endothelial glycocalyx
Daniel Chappell,Dirk Bruegger,Julia Potzel,Matthias Jacob,Florian Brettner,Michael Vogeser,Peter Conzen,Bernhard F. Becker,Markus Rehm +8 more
TL;DR: Data suggest that hypervolemia increases the release of ANP and causes enhanced shedding of the endothelial glycocalyx, implying that VL may not be as safe as generally assumed and that it should be critically evaluated.