Alginate: properties and biomedical applications

Chitosan-based hydrogels for controlled, localized drug delivery

https://cyberleninka.org/article/n/238598.pdf

Use of electrospinning technique for biomedical applications

Biopolymer-based hydrogels as scaffolds for tissue engineering applications: a review

In this review we intend to provide a relatively comprehensive summary of the work of supramolecular hydrogelators after 2004 and to put emphasis particularly on the applications of supramolecular hydrogels/hydrogelators as molecular biomaterials. After a brief introduction of methods for generating supramolecular hydrogels, we discuss supramolecular hydrogelators on the basis of their categories, such as small organic molecules, coordination complexes, peptides, nucleobases, and saccharides. Following molecular design, we focus on various potential applications of supramolecular hydrogels as molecular biomaterials, classified by their applications in cell cultures, tissue engineering, cell behavior, imaging, and unique applications of hydrogelators. Particularly, we discuss the applications of supramolecular hydrogelators after they form supramolecular assemblies but prior to reaching the critical gelation concentration because this subject is less explored but may hold equally great promise for helping ...

Supramolecular Hydrogelators and Hydrogels: From Soft Matter to Molecular Biomaterials

An injectable, in situ enzymatically gellable, gelatin derivative for drug delivery and tissue engineering.

Synthesis and characterization of both ionically and enzymatically cross-linkable alginate.

Chitosan with phenolic hydroxyl groups (Chit-Ph) was synthesized by conjugating chitosan with 3-(p-hydroxyphenyl)propionic acid using aqueous-phase carbodiimide activation chemistry. By this conjugation, we could obtain chitosan derivatives soluble at neutral pH and gellable via a peroxidase-catalyzed reaction within seconds: The Chit-Ph with higher content of Ph groups showed higher solubility at neutral pH. The neutral Chit-Ph solutions gelated via an enzymatic reaction by consuming H2O2. The time necessary for gelation decreased with increasing content of Ph groups, temperature, peroxidase concentration, and decreasing H2O2 concentration. The content of Ph groups also influenced the mechanical property of the resultant gels. In addition, L929 cells, which were contacted to the enzymatically crosslinked Chit-Ph gels for 20 h, showed 96.5% viability, and were observed to grow next to the gels. These results demonstrate that Chit-Ph has the potency for use as injectable hydrogels in applications such as tissue engineering and drug delivery.

Koei Kawakami

Papers

An injectable, in situ enzymatically gellable, gelatin derivative for drug delivery and tissue engineering.

Synthesis and characterization of both ionically and enzymatically cross-linkable alginate.

Novel chitosan derivative soluble at neutral pH and in-situ gellable via peroxidase-catalyzed enzymatic reaction

Fabrication of poly(vinyl alcohol) hydrogel beads crosslinked using sodium sulfate for microorganism immobilization

Synthesis of a chitosan derivative soluble at neutral pH and gellable by freeze–thawing, and its application in wound care