Showing papers in "Acta Biomaterialia in 2007"

TL;DR: It is reasoned through experimental evidence that greater understanding of the mechanics of cancer cell deformability and its interactions with the extracellular physical, chemical and biological environments offers enormous potential for significant new developments in disease diagnostics, prophylactics, therapeutics and drug efficacy assays.

TL;DR: This study proposes a cost-effective composite consisting of a nanofibrous scaffold directly electrospun onto a polyurethane dressing (Tegaderm, 3M Medical) - which it is called the Tegaderm-nanofiber (TG-NF) construct - for dermal wound healing.

TL;DR: The proposed carrier is appropriately suitable for magnetic targeting drug delivery system with longer circulation time, reduced side effects and controlled drug release in response to the change in external temperature.

TL;DR: MTT assay indicated LENS processed porous Ti provides a preferential surface for bone cell proliferation and a critical pore size of 200 microm or higher is needed for cell ingrowth into the pores, below which OPC1 cells bridged the pore surface without any growth in the pores.

TL;DR: In this article, the elastic deformation behavior of a recently developed P-type titanium alloy Ti-24Nb-4Zr-7.9Sn (wt.%) is described.

TL;DR: This work has demonstrated that application of proposed design concepts in combination with laser-engineered net shaping (LENStrade mark) can significantly increase the processing flexibility of complex-shaped metallic implants with three-dimensionally interconnected, designed and functionally graded porosities down to 70vol.

TL;DR: Good agreement was observed between experimental results of scaffold mechanical characterization and low-density, open-cell foam model predictions for uniform scaffolds for in vitro studies of the mechanical interactions between cells and scaffolds as well as in vivo tissue engineering studies.

TL;DR: In this paper, the use of biocomposite material, consisting of poly-e-caprolactone (PCL) and hydroxyapatite (HA), to fabricate tissue engineering (TE) scaffolds using SLS is discussed.

TL;DR: It was clear that rough surface morphology, high surface energy and low values of contact angles were important factors for better cell materials interaction.

TL;DR: The findings suggest that representative cytotoxic responses for humans might be obtained by nanoparticulate exposures to simple murine macrophage cell line assays, and illustrate the utility in performing rapid in vitro assays for cytotoxicity assessments of nanopartsiculate materials as a general inquiry of potential respiratory health risks in humans.

TL;DR: The substantially higher remineralization rate induced by nanometer-sized vs. micrometric bioactive glass particles corroborated the importance of particle size in clinical bioglass applications and was suggested to be attributed to an imperfect arrangement of the newly deposited mineral within the demineralized tooth matrix.

TL;DR: The PMAA-coated nanoferrites are demonstrated as being a potentially superior magnetically targeted drug carrier based on FTIR results and drug release kinetics in the absence and presence of an external magnetic field.

TL;DR: In vitro culture of the encapsulated chondrocyte-encapsulation in the chitosan hydrogel demonstrated that the cells retained round shaped morphology and could survive through a 12d-culture period, although the DNA assay detected an overall reduction of the cell number.

TL;DR: Promising biomedical applications, such as resorbable bone filler or bone substitute releasing in situ Sr ions for a prolonged time, can be hypothesized for the SrHA materials when pathologies related with Sr deficiency are present.

TL;DR: Coating thickness, however, increased with time up to 2h of anodization, at which point an equilibrium thickness was established, and progressively higher values of elastic modulus were obtained for thinner films consistent with increasing effects of the Ti substrate.

TL;DR: Morphological observations, image analyses, mechanical tests and in vitro tests showed that the obtained devices are good candidates as scaffolds for bone-tissue engineering, in terms of pore-size distribution, pore interconnection, surface roughness, and both bioactivity and biocompatibility.

TL;DR: The Cells cultured on the bioglass disks consistently showed a higher alkaline phosphatase activity and cell counts compared to cells cultured on either polystyrene plates or the base CaO-P(2)O(5)-SiO(2)-ZnOBioglass.

TL;DR: Results relate features of the matrix and cellular components of 3-D fibrin constructs to mechanical properties, and contribute to the understanding of structure-function relationships in cell-seeded,3-D protein hydrogels.

TL;DR: In vivo tests of converted shell samples were performed in rat femoral defects for 6 weeks, and results indicate good biocompatibility and bioactivity of the converted shell implants.

TL;DR: Experimental data for the force necessary to pull off single spatulae from hard rough substrates are presented and also observations on living geckos clinging to various surfaces are detail observations on the nano- and macroscales.

TL;DR: Surface characterization and wear studies have shown that in addition to acting as underprop lubricant, CNTs provide reinforcement via stretching and splat-bridging for enhanced abrasion resistance in vitro.

TL;DR: Alginate with phenol moieties in the polymer side chains was synthesized through the conjugation reaction of alginate and tyramine through the oxidative coupling of the phenols and the mechanical properties of the resultant gels were influenced by the preparation conditions of the alginates and the type of cross-linking.

TL;DR: Results showed that fluoride ions were successfully incorporated into the hydroxyapatite (HA) lattice structure and dissolution behavior in Tris-buffered physiological saline indicated that all fluoridated HA coatings had lower solubility than that of the pure HA coating.

TL;DR: Findings indicate that PEGylated fibrinogen hydrogels can be used as a scaffold for cardiomyocytes, and offer the possibility of controlling cellular remodeling via simple compositional modifications to the matrix.

TL;DR: The TiZr alloy after the HA/TiO(2) coatings displayed excellent bone-like apatite-forming ability when soaked in SBF and can be anticipated to be a promising load-bearing implant material.

TL;DR: The results reveal that neither steam nor gamma radiation sterilization entails significant changes of the reduced elastic modulus, hardness or coefficient of friction in the bulk polymer matrix, however, minor material changes ofThe PEEK matrix were observed in the interphase region.

TL;DR: The results of this rabbit model study indicate that titanium alloy mini-implants can be loaded immediately with no compromise in their stability and the vanadium ion release during the healing process.

TL;DR: Examples of protein-mediated functional materials in biology, peptide selection and engineering with affinity to inorganics, demonstrate potential utilizations in materials science, engineering and medicine, and describe future prospects are given.

TL;DR: The structure of untreated as well as chemically and physically treated cuticle from the exoskeleton of the American lobster was investigated using scanning electron microscopy and showed that their structure is more complex than the commonly assumed model for arthropod cuticles.

TL;DR: The apatite-forming ability of the MAO coating is improved remarkably by the simple chemical treatment, since the surface of the alkali-treatedMAO coating could provide abundant Ti-OH groups probably formed by ionic exchanges between (Ca2+, Na+) ions of the alchemical-treated MAO coatings and H3O+ ions of a simulated body fluid (SBF).